Artificial metalloenzymes for enantioselective catalysis based on biotin-avidin

Journal of the American Chemical Society
Jérôme CollotThomas R Ward

Abstract

Homogeneous and enzymatic catalysis offer complementary means to generate enantiomerically pure compounds. Incorporation of achiral biotinylated rhodium-diphosphine complexes into (strept)avidin yields artificial metalloenzymes for the hydrogenation of N-protected dehydroamino acids. A chemogenetic optimization procedure allows one to produce (R)-acetamidoalanine with 96% enantioselectivity. These hybrid catalysts display features reminiscent both of enzymatic and of homogeneous systems.

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Citations

Sep 24, 2013·Applied Microbiology and Biotechnology·Christopher M DundasSheldon Park
Apr 7, 2005·Current Opinion in Chemical Biology·Romas J Kazlauskas
Feb 18, 2004·Protein Expression and Purification·Andrea ZocchiThomas R Ward
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Sep 20, 2008·Chemical Communications : Chem Comm·Anca Pordea, Thomas R Ward
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