Artificial rearing alters the response of rats to natural and drug-mediated rewards

Developmental Psychobiology
Anna M LomanowskaPatricia E Wainwright

Abstract

Artificial rearing (AR) of infant rats permits precise control over key features of the early environment without maternal influence. The present study examined the behavioral response of AR rats towards natural and drug-mediated rewards, as well as their exploratory and affective behaviors. Adolescent AR rats showed increased preference for sucrose consumption relative to chow and demonstrated greater activity in the open field and in the elevated plus-maze compared to maternally reared (MR) rats. With respect to measures of emotionality, AR rats showed enhanced avoidance of the open arms of the plus-maze, indicating increased anxiety, but they did not differ from MR rats in exploring the center of the open field. Adult AR rats displayed a stronger conditioned response to morphine in a place preference test. These findings support the potential of the AR model to contribute to understanding the role of early experience in the development of behavioral motivation.

References

Dec 26, 1975·Science·W G Hall
Jul 1, 1988·Pflügers Archiv : European journal of physiology·A A Young, N J Dawson
Jan 1, 1971·Developmental Psychobiology·S A BarnettE M Widdowson
Sep 1, 1984·The British Journal of Nutrition·J L SmartJ Edmond
Jun 1, 1983·Physiology & Behavior·J E Jans, M Leon
Jun 1, 1994·Acta Paediatrica. Supplement·M A Hofer
Mar 1, 1994·Developmental Psychobiology·B G Galef, M A Smith
Jan 1, 1997·Developmental Psychobiology·G S FloryJ R Alberts
Jan 1, 1996·Depression and Anxiety·W M KanekoC L Ehlers
May 14, 1998·Preventive Medicine·T Field
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C M Kuhn, S M Schanberg
Mar 11, 1999·Current Opinion in Neurobiology·D D Francis, M J Meaney
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·S J KellyM A Wilson
Apr 14, 2000·Journal of Child Psychology and Psychiatry, and Allied Disciplines·D Glaser
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·T A GirardP E Wainwright
May 30, 2001·Neuroscience and Biobehavioral Reviews·P Palanza
Aug 23, 2001·Experimental Animals·H HashimotoK W Takahashi
Oct 30, 2001·Behavioural Brain Research·P E Wainwright
Feb 23, 2002·Scientific American·Martin H Teicher

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Citations

Jun 14, 2006·Behavioral Neuroscience·Christie BurtonAlison S Fleming
Feb 1, 2011·Behavioural Brain Research·Anna M LomanowskaGary W Kraemer
Oct 24, 2007·Peptides·Richard J Bodnar
Aug 28, 2010·Developmental Psychobiology·Vedran LovicAlison S Fleming
Oct 4, 2011·Hormones and Behavior·Veronica M AfonsoAlison S Fleming
Jul 28, 2011·Stress : the International Journal on the Biology of Stress·A M LomanowskaG W Kraemer

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