Artificial Selection Response due to Polygenic Adaptation from a Multilocus, Multiallelic Genetic Architecture

Molecular Biology and Evolution
Yanjun ZanOrjan Carlborg


The ability of a population to adapt to changes in their living conditions, whether in nature or captivity, often depends on polymorphisms in multiple genes across the genome. In-depth studies of such polygenic adaptations are difficult in natural populations, but can be approached using the resources provided by artificial selection experiments. Here, we dissect the genetic mechanisms involved in long-term selection responses of the Virginia chicken lines, populations that after 40 generations of divergent selection for 56-day body weight display a 9-fold difference in the selected trait. In the F15 generation of an intercross between the divergent lines, 20 loci explained >60% of the additive genetic variance for the selected trait. We focused particularly on fine-mapping seven major QTL that replicated in this population and found that only two fine-mapped to single, bi-allelic loci; the other five contained linked loci, multiple alleles or were epistatic. This detailed dissection of the polygenic adaptations in the Virginia lines provides a deeper understanding of the range of different genome-wide mechanisms that have been involved in these long-term selection responses. The results illustrate that the genetic architecture...Continue Reading


Oct 1, 1996·Poultry Science·E A Dunnington, Paul B Siegel
Oct 30, 2001·Evolution; International Journal of Organic Evolution·C G KnightA M Leroi
Jul 3, 2004·Trends in Plant Science·Stephen P MooseTorbert R Rocheford
Feb 5, 2005·Science·William G Hill
May 6, 2005·Nature·Juergen Kroymann, Thomas Mitchell-Olds
Jan 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ioannis M StylianouGary A Churchill
Mar 15, 2006·Nature Genetics·Orjan CarlborgLeif Andersson
Apr 21, 2006·Genetics·Venu KalavacharlaShahryar F Kianian
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Apr 17, 2007·Genetics·Sinéad CollinsClaudia Acquisti
Jan 13, 2009·Nature Genetics·Henrique TeotónioAnthony D Long
May 5, 2009·Genome Research·Jonathan Flint, Trudy F C Mackay
May 29, 2009·Genetics·William ValdarJonathan Flint
Aug 8, 2009·Science·Edward S BucklerMichael D McMullen
Apr 21, 2010·Cell·Jon McClellan, Mary-Claire King
Sep 15, 2010·Nature Reviews. Genetics·Jonathan K Pritchard, Anna Di Rienzo
Sep 21, 2010·Trends in Genetics : TIG·Nicola J Nadeau, Chris D Jiggins
Nov 17, 2010·PLoS Genetics·Anna M JohanssonOrjan Carlborg
Jan 19, 2011·Genetics, Selection, Evolution : GSE·Francois BesnierOrjan Carlborg
Oct 8, 2011·Science·A Fournier-LevelA M Wilczek
Jan 10, 2012·Evolution; International Journal of Organic Evolution·Matthew V Rockman
Nov 17, 2012·Nature Reviews. Genetics·Carrie F Olson-ManningThomas Mitchell-Olds
Mar 16, 2013·Science·Catherine R LinnenHopi E Hoekstra
Sep 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Luis BarbozaRubén Alcázar
Oct 19, 2013·Nature Reviews. Genetics·Outi SavolainenJuha Merilä
Oct 31, 2013·G3 : Genes - Genomes - Genetics·Mats E PetterssonOrjan Carlborg
Mar 13, 2014·Nature Reviews. Genetics·Annalise B Paaby, Matthew V Rockman
Jun 16, 2014·Bioinformatics·Zuguang GuBenedikt Brors

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