Artificial Selection Response due to Polygenic Adaptation from a Multilocus, Multiallelic Genetic Architecture

Molecular Biology and Evolution
Yanjun ZanOrjan Carlborg

Abstract

The ability of a population to adapt to changes in their living conditions, whether in nature or captivity, often depends on polymorphisms in multiple genes across the genome. In-depth studies of such polygenic adaptations are difficult in natural populations, but can be approached using the resources provided by artificial selection experiments. Here, we dissect the genetic mechanisms involved in long-term selection responses of the Virginia chicken lines, populations that after 40 generations of divergent selection for 56-day body weight display a 9-fold difference in the selected trait. In the F15 generation of an intercross between the divergent lines, 20 loci explained >60% of the additive genetic variance for the selected trait. We focused particularly on fine-mapping seven major QTL that replicated in this population and found that only two fine-mapped to single, bi-allelic loci; the other five contained linked loci, multiple alleles or were epistatic. This detailed dissection of the polygenic adaptations in the Virginia lines provides a deeper understanding of the range of different genome-wide mechanisms that have been involved in these long-term selection responses. The results illustrate that the genetic architecture...Continue Reading

Citations

Oct 1, 1996·Poultry Science·E A Dunnington, Paul B Siegel
Oct 30, 2001·Evolution; International Journal of Organic Evolution·C G KnightA M Leroi
Jul 3, 2004·Trends in Plant Science·Stephen P MooseTorbert R Rocheford
Feb 5, 2005·Science·William G Hill
May 6, 2005·Nature·Juergen Kroymann, Thomas Mitchell-Olds
Jan 18, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Ioannis M StylianouGary A Churchill
Mar 15, 2006·Nature Genetics·Orjan CarlborgLeif Andersson
Apr 21, 2006·Genetics·Venu KalavacharlaShahryar F Kianian
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Apr 17, 2007·Genetics·Sinéad CollinsClaudia Acquisti
Jan 13, 2009·Nature Genetics·Henrique TeotónioAnthony D Long
May 5, 2009·Genome Research·Jonathan Flint, Trudy F C Mackay
May 29, 2009·Genetics·William ValdarJonathan Flint
Aug 8, 2009·Science·Edward S BucklerMichael D McMullen
Apr 21, 2010·Cell·Jon McClellan, Mary-Claire King
Sep 15, 2010·Nature Reviews. Genetics·Jonathan K Pritchard, Anna Di Rienzo
Sep 21, 2010·Trends in Genetics : TIG·Nicola J Nadeau, Chris D Jiggins
Nov 17, 2010·PLoS Genetics·Anna M JohanssonOrjan Carlborg
Jan 19, 2011·Genetics, Selection, Evolution : GSE·Francois BesnierOrjan Carlborg
Oct 8, 2011·Science·A Fournier-LevelA M Wilczek
Jan 10, 2012·Evolution; International Journal of Organic Evolution·Matthew V Rockman
Nov 17, 2012·Nature Reviews. Genetics·Carrie F Olson-ManningThomas Mitchell-Olds
Mar 16, 2013·Science·Catherine R LinnenHopi E Hoekstra
Sep 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Luis BarbozaRubén Alcázar
Oct 19, 2013·Nature Reviews. Genetics·Outi SavolainenJuha Merilä
Oct 31, 2013·G3 : Genes - Genomes - Genetics·Mats E PetterssonOrjan Carlborg
Mar 13, 2014·Nature Reviews. Genetics·Annalise B Paaby, Matthew V Rockman
Jun 16, 2014·Bioinformatics·Zuguang GuBenedikt Brors

Related Concepts

Gene Polymorphism
Study
Quantitative Trait Loci
Equine Laminitis
Genome
Genes
Polygenic Inheritance
Acclimatization
Genetics, Population
Weighing Patient

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.