Artificial shrinkage of blastocysts prior to vitrification improves pregnancy outcome: analysis of 1028 consecutive warming cycles

Journal of Assisted Reproduction and Genetics
Paolo Emanuele Levi-SettiElena Albani

Abstract

This study aims to compare implantation, pregnancy, and delivery rates in frozen transfer cycles with blastocysts that were vitrified either with artificial shrinking (AS group) or without (NAS group). Retrospective comparative study of artificial shrinking of blastocysts prior to vitrification and frozen embryo transfer cycles in infertile patients undergoing frozen embryo transfer (FET) was done at the Humanitas Fertility Center between October 2009 and December 2013. Main outcome measure(s) were implantation (IR), pregnancy (PR), and delivery rates (DR) between the two groups. A total of 1028 consecutive warming blastocyst transfer cycles were considered. In 580 cycles (total of 822 blastocysts), artificial shrinking was performed prior to vitrification (AS group), while in the remaining 448 cycles (total of 625 blastocysts), the artificial shrinking was not performed (NAS group). There were no differences in patient age (36.4 ± 3.7 vs. 36.3 ± 3.9) and number of embryos transferred (1.41 ± 0.49 vs. 1.38 ± 0.50) between groups. The IR, PR, and DR in the AS group were significantly higher (p < 0.05) than in the NAS group (29.9 vs. 23.0 %, 36.3 vs. 27.9 %, and 26.5 vs. 18.1 %, respectively). Performing AS of blastocysts prior t...Continue Reading

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Citations

Jan 25, 2020·Human Fertility : Journal of the British Fertility Society·Juliette BoyardThomas Fréour
Apr 28, 2017·Reproductive Biology and Endocrinology : RB&E·Caizhu WangZhulian Wu
Jun 30, 2019·Zygote : the Biology of Gametes and Early Embryos·D MontjeanP Boyer
Jun 17, 2020·Human Fertility : Journal of the British Fertility Society·Caizhu WangHong Zhou
Jun 18, 2020·Frontiers in Endocrinology·Paolo Emanuele Levi SettiPasquale Patrizio
Dec 8, 2016·Journal of Assisted Reproduction and Genetics·Gabriella TedeschiPaolo Emanuele Levi-Setti
Jul 18, 2019·Reproductive Medicine and Biology·Shingo MitsuhataHiroaki Motoyama
Feb 19, 2021·Zygote : the Biology of Gametes and Early Embryos·Shun XiongGuo Ning Huang
Mar 2, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Manal Kamel MohamedMahmoud Alalfy
Sep 23, 2021·Journal of Assisted Reproduction and Genetics·Roni Rahav-KorenArie Berkowitz

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