Artificial Signal Transduction.

ChemistryOpen
Robert Bekus, Thomas Schrader

Abstract

Communication between and inside cells as well as their response to external stimuli relies on elaborated systems of signal transduction. They all require a directional transmission across membranes, often realized by primary messenger docking onto external receptor units and subsequent internalization of the signal in form of a released second messenger. This in turn starts a cascade of events which ultimately control all functions of the living cell. Although signal transduction is a fundamental biological process realized by supramolecular recognition and multiplication events with small molecules, chemists have just begun to invent artificial models which allow to study the underlying rules, and one day perhaps to rescue damaged transduction systems in nature. This review summarizes the exciting pioneering efforts of chemists to create simple models for the basic principles of signal transduction across a membrane. It starts with first attempts to establish molecular recognition events on liposomes with embedded receptor amphiphiles and moves on to simple transmembrane signaling across lipid bilayers. More elaborated systems step by step incorporate more elements of cell signaling, such as primary and secondary messenger or...Continue Reading

References

Jan 30, 1991·Biochimica Et Biophysica Acta·R C MacDonaldL R Hu
Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·K Simons, D Toomre
Oct 19, 2002·Angewandte Chemie·Patrick BartonNicholas H Williams
Apr 10, 2003·Journal of the American Chemical Society·Emma L DoyleNicholas H Williams
Jul 30, 2003·Biophysical Journal·Philipus J Patty, Barbara J Frisken
Apr 28, 2004·Chemistry : a European Journal·Valérie Marchi-ArtznerJean-Marie Lehn
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Antoine RichardJean-Marie Lehn
Dec 13, 2005·Angewandte Chemie·Jochen R PfeiferUlrich Koert
Mar 22, 2006·Chemical Communications : Chem Comm·Hua Jiang, Bradley D Smith
Oct 13, 2006·Journal of the American Chemical Society·Sofiya KolushevaRaz Jelinek
Nov 23, 2006·Journal of Receptor and Signal Transduction Research·Thomas SchraderManuel Ellermann
Nov 3, 2007·Current Opinion in Chemical Biology·Yee-Hung M Chan, Steven G Boxer
Jan 2, 2010·Science·Daniel Lingwood, Kai Simons
Feb 5, 2010·Journal of Cell Science·Marek CebecauerAnthony I Magee
May 27, 2010·Beilstein Journal of Organic Chemistry·Andreas Späth, Burkhard König
Jun 19, 2010·Organic & Biomolecular Chemistry·Benjamin GruberBurkhard König
Jul 7, 2010·Cell·Mark A Lemmon, Joseph Schlessinger
Feb 18, 2011·Chemistry : a European Journal·Craig P WilsonSimon J Webb
Jul 20, 2012·Nature Chemical Biology·Sébastien Granier, Brian Kobilka
Feb 13, 2013·Journal of the American Chemical Society·Supratim Banerjee, Burkhard König
Feb 26, 2013·Nanoscale Research Letters·Abolfazl AkbarzadehKazem Nejati-Koshki
Apr 4, 2013·Accounts of Chemical Research·Andreas Vargas JentzschStefan Matile
May 8, 2013·Angewandte Chemie·Robert J Lefkowitz
May 18, 2013·Chemical Communications : Chem Comm·Supratim BanerjeeBurkhard König
Jun 5, 2013·Methods in Molecular Biology·Heiko KellerPetra Schwille
Nov 14, 2013·Chemistry and Physics of Lipids·Yogita P Patil, Sameer Jadhav
Mar 13, 2014·Nature Medicine·Mark MapstoneHoward J Federoff
Sep 11, 2014·Chemical Communications : Chem Comm·Andreas Müller, Burkhard König
Oct 10, 2014·Journal of the American Chemical Society·Takahiro MuraokaKazushi Kinbara
Jan 31, 2015·Nature Communications·Dragomir MilovanovicReinhard Jahn
Apr 29, 2015·Nature Chemical Biology·Sung-Tae YangLukas K Tamm
Sep 9, 2015·Journal of Cell Science·Caitlin D Hanlon, Deborah J Andrew
Nov 19, 2015·Journal of Bone Oncology·Aude I SégalinyDominique Heymann
Dec 10, 2015·Frontiers in Pharmacology·Lisa SercombeSusan Hua
May 8, 2016·Immunology·Pallavi VarshneyNeeru Saini
Aug 31, 2016·Journal of Molecular Biology·Ilya Levental, Sarah Veatch
Mar 31, 2017·Nature Reviews. Molecular Cell Biology·Erdinc SezginChristian Eggeling
Apr 6, 2017·Chemical Society Reviews·Philip A GaleRoberto Quesada
Apr 22, 2017·Nature Chemistry·Matthew J LangtonChristopher A Hunter
May 4, 2017·Journal of the American Chemical Society·Matthew J LangtonChristopher A Hunter
Jun 22, 2017·Chemical Communications : Chem Comm·Alberto FuertesJavier Montenegro
Sep 7, 2017·Journal of the American Chemical Society·Matthew J LangtonChristopher A Hunter
Oct 13, 2017·Angewandte Chemie·Shu PengAndreas Hennig
Jan 13, 2018·Nature Structural & Molecular Biology·Daniel HilgerBrian K Kobilka
Feb 8, 2018·Nature Reviews. Molecular Cell Biology·Takeshi Harayama, Howard Riezman
Feb 15, 1999·Angewandte Chemie·Maureen M TedescoStefan Matile
Aug 1, 2018·Accounts of Chemical Research·Xin WuPhilip A Gale

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Methods Mentioned

BETA
Fluorescence
FRET
fluorescence microscopy
dynamic light scattering

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