PMID: 7015781Sep 1, 1980Paper

Artificial ventilation of premature newborn rabbits: effects of positive end-expiratory pressure on lung mechanics and lung morphology

Acta paediatrica Scandinavica
R NilssonB Robertson

Abstract

44 premature newborn rabbits, removed by hysterotomy on day 27 of gestation, were ventilated with positive pressure under differing standardized conditions, with or without application of positive end-expiratory pressure (PEEP; 5 cm H2O). After 10 min ventilation, compliance of the lung-thorax system was significantly higher in fetuses ventilated with PEEP than in controls. The application of PEEP also resulted in a significantly lower maximal expiratory air flow compared to controls in groups ventilated with standardized tidal volume. Morphometric evaluation revealed bronchiolar epithelial lesions to be less prominent in fetuses treated with PEEP. Our findings show that application of PEEP has a beneficial effect on lung mechanics during artificial ventilation and that it reduces the risk of epithelial damage to the airways, presumably by promoting uniform expansion of the lung parenchyma.

References

Jan 1, 1978·Biology of the Neonate·T H ShafferM Delivoria-Papadopoulos
Dec 1, 1979·Respiration Physiology·B LachmannB Robertson
Jan 1, 1976·Biology of the Neonate·G H Schwieler, B Robertson
Jan 1, 1972·Journal of Applied Physiology·J M HughesJ Mead
Jan 1, 1980·Respiration; International Review of Thoracic Diseases·R NilssonB Robertson

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Citations

Feb 11, 2009·Clinical and Experimental Pharmacology & Physiology·Stuart B HooperMegan J Wallace
Jun 3, 2008·Seminars in Fetal & Neonatal Medicine·Colm P F O'Donnell, Benjamin J Stenson
Mar 15, 2006·Clinics in Perinatology·Benjamin J StensonEdgardo G Szyld
Mar 11, 2004·Journal of Paediatrics and Child Health·C P F O'DonnellC J Morley
Sep 21, 2007·Physics in Medicine and Biology·Nancy L FordMaria Drangova
Mar 17, 2009·Physics in Medicine and Biology·N L FordM Drangova
Nov 1, 1980·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·R NilssonB Robertson
Apr 1, 2011·Pediatric Research·Melissa L SiewStuart B Hooper
Mar 27, 2009·Physics in Medicine and Biology·G CaoO Zhou

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