Artificially Reprogrammed Macrophages as Tumor-Tropic Immunosuppression-Resistant Biologics to Realize Therapeutics Production and Immune Activation

Advanced Materials
Chu-Xin LiXian-Zheng Zhang

Abstract

To engineer patient-derived cells into therapy-purposed biologics is a promising solution to realize personalized treatments. Without using gene-editing technology, a live cell-typed therapeutic is engineered for tumor treatment by artificially reprogramming macrophages with hyaluronic acid-decorated superparamagnetic iron oxide nanoparticles (HIONs). This nanoparticle-assisted cell-reprogramming strategy demonstrates profound advantages, due to the combined contributions from the biological regulation of HIONs and the intrinsic nature of macrophages. Firstly, the reprogrammed macrophages present a substantial improvement in their innate capabilities, such as more effective tumor targeting and more efficient generation of bioactive components (e.g., reactive oxygen species, bioactive cytokines) to suppress tumor growth. Furthermore, this cell therapeutic exhibits cytostatic/proapoptotic effects specific to cancer cells. Secondly, HIONs enable macrophages more resistant to the intratumoral immunosuppressive environment. Thirdly, the macrophages are endowed with a strong ability to prime in situ protumoral M2 macrophages into antitumor M1 phenotype in a paracrine-like manner. Consequently, a synergistic tumor-inhibition effect is...Continue Reading

References

Apr 1, 1998·Nature·J Banchereau, R M Steinman
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Dec 10, 2002·American Journal of Respiratory and Critical Care Medicine·Henry Jay Forman, Martine Torres
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven A RosenbergSeth M Steinberg
Apr 15, 2006·The Oncologist·Remco van HorssenAlexander M M Eggermont
Oct 5, 2007·Critical Reviews in Oncology/hematology·Paola AllavenaAlberto Mantovani
Mar 11, 2010·Advanced Materials·Jian XuDavid A LaVan
May 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chao ShiEric G Pamer
Jan 1, 2009·Journal of Materials Chemistry·Chen Fang, Miqin Zhang
Aug 17, 2010·Nature Medicine·Matthias T StephanDarrell J Irvine
Feb 15, 2011·The Journal of Clinical Investigation·Anca SindrilaruKarin Scharffetter-Kochanek
Oct 11, 2011·Nature Reviews. Immunology·Chao Shi, Eric G Pamer
Oct 15, 2011·Nature Reviews. Immunology·Peter J Murray, Thomas A Wynn
Jul 9, 2014·Nature Reviews. Clinical Oncology·Ignacio MeleroHåkan Mellstedt
Sep 11, 2014·Nature Communications·Ke ChengEduardo Marbán
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A PostowJedd D Wolchok
Jun 6, 2015·Cell Research·Beth Kelly, Luke A J O'Neill
Jun 25, 2016·Nature Reviews. Cancer·Camilla EngblomMikael J Pittet
Nov 1, 2016·Nature Nanotechnology·Saeid ZanganehHeike Elisabeth Daldrup-Link
Nov 29, 2016·Advanced Materials·Can XuXiaoyuan Chen
Jun 21, 2017·Biomaterials·Natalia L KlyachkoElena V Batrakova
Oct 31, 2017·Nature Chemical Biology·Zhaowei ChenZhen Gu
Apr 16, 2018·Advanced Materials·Xudong ZhangZhen Gu
Jun 5, 2018·Nature Biomedical Engineering·Junnan TangKe Cheng
Jun 22, 2018·Advanced Materials·Di-Wei ZhengXian-Zheng Zhang
Jul 10, 2018·Nature Biotechnology·Li TangDarrell J Irvine
Jul 18, 2018·Advanced Materials·Wen-Long LiuXian-Zheng Zhang

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Citations

Jun 5, 2020·Science Advances·C Wyatt ShieldsSamir Mitragotri
Apr 17, 2020·Angewandte Chemie·Shuangqian YanXiaogang Liu
Aug 29, 2020·Advanced Materials·Yuqiong XiaXiaoyuan Chen
Nov 21, 2019·Angewandte Chemie·Kanyi Pu, Hai-Yan Xie
Jun 20, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Qianmin ZhangLingqian Chang
Nov 3, 2020·Advanced Healthcare Materials·Hung-Wei ChengSan-Yuan Chen
Nov 24, 2020·Chemical Society Reviews·Guo-Feng LuoXian-Zheng Zhang
Feb 11, 2021·Advanced Materials·Jinhua LiZhen Gu
Feb 16, 2021·Frontiers in Chemistry·Amreen KhanRohit Srivastava
Mar 4, 2021·Biomedical Materials·Xiaqing Wu, Haiyuan Zhang
Feb 26, 2021·Oxidative Medicine and Cellular Longevity·Lesang ShenJian Huang
Sep 6, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Weishuo LiCan Zhang
Jul 22, 2021·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Seokhwan ChungMiqin Zhang
Aug 6, 2021·Biomedical Engineering Letters·Na Yeon Kim, Ji-Ho Park
May 30, 2021·Advanced Materials·Jun-Long LiangXian-Zheng Zhang
Dec 3, 2021·Nanomedicine·Camila Sales NascimentoCarlos Eduardo Calzavara-Silva

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