Artificially Sweetened Beverages and Stroke, Coronary Heart Disease, and All-Cause Mortality in the Women's Health Initiative

Stroke; a Journal of Cerebral Circulation
Yasmin Mossavar-RahmaniSylvia Wassertheil-Smoller

Abstract

Background and Purpose- We examine the association between self-reported consumption of artificially sweetened beverages (ASB) and stroke and its subtypes, coronary heart disease, and all-cause mortality in a cohort of postmenopausal US women. Methods- The analytic cohort included 81 714 women from the Women's Health Initiative Observational Study, a multicenter longitudinal study of the health of 93 676 postmenopausal women of ages 50 to 79 years at baseline who enrolled in 1993 to 1998. This prospective study had a mean follow-up time of 11.9 years (SD of 5.3 years.) Participants who completed a follow-up visit 3 years after baseline were included in the study. Results- Most participants (64.1%) were infrequent consumers (never or <1/week) of ASB, with only 5.1% consuming ≥2 ASBs/day. In multivariate analyses, those consuming the highest level of ASB compared to never or rarely (<1/wk) had significantly greater likelihood of all end points (except hemorrhagic stroke), after controlling for multiple covariates. Adjusted models indicated that hazard ratios and 95% confidence intervals were 1.23 (1.02-1.47) for all stroke; 1.31 (1.06-1.63) for ischemic stroke; 1.29 (1.11-1.51) for coronary heart disease; and 1.16 (1.07-1.26) for...Continue Reading

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Citations

Sep 4, 2019·JAMA Internal Medicine·Amy MulleeNeil Murphy
Jan 30, 2020·Circulation·Salim S ViraniUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Feb 16, 2020·American Journal of Hypertension·Panayiotis LoucaSandosh Padmanabhan
Jun 10, 2020·Public Health Nutrition·Ana Clara DuranAna Paula Bortoletto Martins
Jan 15, 2020·European Cardiology·Amelia Carro, Josefa María Panisello
Feb 15, 2019·Stroke; a Journal of Cerebral Circulation·Hannah Gardener, Mitchell S V Elkind
Nov 20, 2019·Current Atherosclerosis Reports·Yoona KimPeter M Clifton
Apr 13, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Sydney RisdonGuillaume Walther
Sep 2, 2021·Ciência & saúde coletiva·Jordana Herzog SiqueiraMaria Del Carmen Bisi Molina
Nov 13, 2019·Metabolism: Clinical and Experimental·Chrysoula BoutariChristos S Mantzoros

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