PMID: 6992062Feb 1, 1980Paper

Artificially transformed schistosomula of Schistosoma mansoni: mechanism of acquisition of protection against antibody-mediated killing

Parasitology
C A TavaresG Gazzinelli

Abstract

Incorporation of labelled amino acid into tegumental proteins and acquisition of protection by schistosomula against antibody-mediated killing in vitro were simultaneously stimulated by serum factors and inhibited by puromycin. Comparison of polyacrylamide gel electrophoresis patterns with fluorographic autoradiography indicates that the majority of proteins in the parasite tegument were labelled with the isotope after incubation for 3 h. No new, clearly defined band was observed in the autoradiography pattern. During this period a decreasing susceptibility of the schistosomula to antibody plus complement was observed. Quantitative fluorescence assay shows that schistosomula insensitive to antibody plus complement were still able to bind the same amount of antibody as the unprotected parasites. Pre-culture of schistosomula in the presence of inactivated normal rabbit serum also decreased the susceptibility of the parasites to the in vivo killing mechanism.

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Citations

Apr 1, 1984·Molecular and Biochemical Parasitology·M Nascimento CordeiroE Alvarenga Figueiredo
Sep 1, 1984·Molecular and Biochemical Parasitology·D P ThompsonJ L Bennett
Nov 1, 1986·Molecular and Biochemical Parasitology·J F ParraT A Mota-Santos
Jan 15, 1987·Molecular and Biochemical Parasitology·M V Rogers, D J McLaren
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guofa ZhouGuiyun Yan
Mar 29, 2012·BMJ : British Medical Journal·Anna M CheckleyChristopher J M Whitty
Aug 2, 2008·BMC Infectious Diseases·Daibin ZhongGuiyun Yan
Nov 10, 2013·PLoS Neglected Tropical Diseases·Leonardo P FariasLuciana C C Leite
May 25, 2002·Emerging Infectious Diseases·Simon I HayRobert W Snow
May 25, 2002·Emerging Infectious Diseases·Simon I HayRobert W Snow
Dec 2, 2005·Emerging Infectious Diseases·Otsyula G MunyekenyeGuiyun Yan
Jun 8, 2007·Emerging Infectious Diseases·Tarekegn A Abeku
Nov 1, 1984·Molecular and Biochemical Parasitology·F Levi-SchafferM Smolarsky
Jan 1, 1990·European Journal of Immunology·M MarikovskyZ Fishelson
Jan 1, 1989·Parasitology Today·Z Fishelson
Oct 1, 2007·Expert Opinion on Drug Discovery·Bernadette RamirezSolomon Nwaka
Apr 1, 1982·Experimental Parasitology·D J McLaren, R N Incani
Jan 1, 1982·Immunological Reviews·A E ButterworthE Wells
Aug 1, 1988·Annals of Tropical Medicine and Parasitology·J A Nogueira-MachadoM C Moreira

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