Artrogryposis multiplex congenita -- a rare fetal condition caused by maternal myasthenia gravis

Acta Neurologica Scandinavica. Supplementum
J M HoffN E Gilhus

Abstract

To look at the occurrence of arthrogryposis multiplex congenita in newborn of mothers with myasthenia gravis (MG) and factors connected to this. We retrospectively studied 176 births by 79 MG mothers, recorded in the Medical Birth Registry of Norway (MBRN). Four (2.2%) newborns (including one pair of twins) born with severe skeletal anomalies were identified. All four children died. Three had findings consistent with arthrogryposis multiplexa congenita (AMC), one had a fetal akinesia deformation sequence (FADS). The mother of the child with FADS had previously given birth to a child with neonatal MG. She was now in complete MG remission. The mother of the twins with AMC later gave birth to a child with neonatal MG. Siblings of an affected child -- either with neonatal MG or AMC -- have an increased risk to develop either neonatal MG or AMC. As this appears to be independent of the MG mother's clinical state, it is important to discuss previous pregnancy outcomes with all female MG patients.

References

Feb 20, 1999·Neurology·A P BatocchiP Tonali
May 8, 2000·American Journal of Medical Genetics·L A BruetonA Vincent
Jul 20, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Josip DjelmisMarina Ivanisevic
Nov 26, 2003·Neurology·Jana Midelfart HoffNils Erik Gilhus
Jul 27, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J M HoffN E Gilhus

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Citations

Jun 3, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J-C WenW-C Tsai
Oct 11, 2012·ISRN Obstetrics and Gynecology·Emmanouil KalampokasDimitrios Botsis
Oct 21, 2015·Journal of Children's Orthopaedics·Jana Midelfart Hoff, Anna Midelfart
Dec 4, 2008·Advances in Pediatrics·Alice Chang HoftmanE Richard Stiehm
Jun 20, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anca Maria Panaitescu, Kypros Nicolaides
Mar 11, 2009·Expert Review of Neurotherapeutics·Nils Erik Gilhus
Aug 1, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Judith G Hall
Jan 31, 2016·Archives of Gynecology and Obstetrics·Astrid HellmundUlrich Gembruch
Aug 19, 2020·Diagnostics·Anca Marina CiobanuAnca Maria Panaitescu
Jun 24, 2018·Molecular Psychiatry·Karen L Jones, Judy Van de Water

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