Arundic acid attenuates retinal ganglion cell death by increasing glutamate/aspartate transporter expression in a model of normal tension glaucoma

Cell Death & Disease
M YanagisawaKohichi Tanaka

Abstract

Glaucoma is the second leading cause of blindness worldwide and is characterized by gradual visual impairment owing to progressive loss of retinal ganglion cells (RGCs) and their axons. Glutamate excitotoxicity has been implicated as a mechanism of RGC death in glaucoma. Consistent with this claim, we previously reported that glutamate/aspartate transporter (GLAST)-deficient mice show optic nerve degeneration that is similar to that observed in glaucoma. Therefore, drugs that upregulate GLAST may be useful for neuroprotection in glaucoma. Although many compounds are known to increase the expression of another glial glutamate transporter, EAAT2/GLT1, few compounds are shown to increase GLAST expression. Arundic acid is a glial modulating agent that ameliorates delayed ischemic brain damage by attenuating increases in extracellular glutamate. We hypothesized that arundic acid neuroprotection involves upregulation of GLAST. To test this hypothesis, we examined the effect of arundic acid on GLAST expression and glutamate uptake. We found that arundic acid induces GLAST expression in vitro and in vivo. In addition, arundic acid treatment prevented RGC death by upregulating GLAST in heterozygous (GLAST(+/-)) mice. Furthermore, arundi...Continue Reading

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Citations

Apr 20, 2016·European Journal of Pharmacology·Nucci CarloMorrone Luigi Antonio
Oct 22, 2008·Progress in Brain Research·Rossella RussoLuigi Antonio Morrone
Jul 6, 2004·American Journal of Ophthalmology·Simon K LawJoseph Caprioli
Aug 5, 2015·Chemistry : a European Journal·Steve SaulnierPier Giorgio Cozzi
Oct 26, 2021·Frontiers in Physiology·Isato FukushiYasumasa Okada

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BETA
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transfection
Assay
electrophoresis

Software Mentioned

Leica Application Suite
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