Aryl hydrocarbon receptor and unexplained miscarriage

The Journal of Obstetrics and Gynaecology Research
Hongjie FanAimin Zhao

Abstract

The aim of this study was to carry out a preliminary investigation of the expression of aryl hydrocarbon receptor (AhR) in decidua and villus and the relationship between AhR and unexplained miscarriage. The expression of AhR mRNA and protein from decidua and villus were measured using real-time reverse transcription-polymerase chain reaction, western blot and immunohistochemistry in 34 patients with unexplained miscarriage (miscarriage group) and 38 women with normal early pregnancy (control group). The AhR mRNA and protein expression was increased significantly in the villus in both groups compared with decidua (P < 0.05, P < 0.05). In decidua, AhR mRNA and protein expression in the miscarriage group was increased significantly compared with the control group (P < 0.05, P < 0.05). In villus, AhR mRNA and protein expression in the miscarriage group was increased significantly compared with the control group (P < 0.05, P < 0.05). AhR is expressed mostly in the cytoplasm of syncytiotrophoblasts in villus, and also in the cytoplasm of decidual cells. AhR was expressed more in the villus than in the decidua, and the upregulation of AhR mRNA and protein expression is associated with the pathogenesis of unexplained miscarriage.

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Citations

Jun 18, 2019·The Cochrane Database of Systematic Reviews·Marike LemmersJames P Neilson
Jul 28, 2020·Biology of Reproduction·Yan LiJing Zheng
Nov 30, 2018·International Journal of Molecular Sciences·Anaïs WakxIoana Ferecatu
Dec 27, 2017·Journal of Applied Toxicology : JAT·Gaston OtarolaSylvain Marcellini
Mar 23, 2021·Frontiers in Immunology·Maria Florencia TortiCybele Carina García
Jul 14, 2021·Toxicology and Applied Pharmacology·Violet KlenovAileen F Keating

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