PMID: 7545952Sep 1, 1994Paper

Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro

The Biochemical Journal
S L Kelly, E Sim

Abstract

Three genes encoding arylamine N-acetyltransferase were identified in Balb/c mice. All three genes were cloned from genomic DNA, sequenced and expressed in a bacterial expression system. Two of the genes corresponded to Nat-1 and Nat-2 which have been previously identified in A/J and C57B1/6 strains of mice (Martell et al., 1991). The new gene, designated Nat-3, can be distinguished from the other mouse Nat genes both by specific amplification using PCR and by restriction-endonuclease digestion. The products of all three genes are demonstrated to catalyse acetylation of aminofluorene and anisidine following expression in Escherichia coli.

Citations

Jul 22, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jennifer A LoehleDavid W Hein
Sep 19, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David F BarkerDavid W Hein
Jul 4, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·K S SugamoriD M Grant
Apr 23, 2002·Pharmacogenomics·Frédérique PompeoEdith Sim
May 6, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Larissa WakefieldEdith Sim
Jul 22, 2008·Drug Metabolism Reviews·Edith SimSotiria Boukouvala
Apr 4, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·K S SugamoriD M Grant
Apr 13, 2007·Expert Opinion on Drug Metabolism & Toxicology·Edith SimElizabeth Fullam
May 7, 2002·The Pharmacogenomics Journal·N J ButcherR F Minchin
Nov 1, 2005·Drug Metabolism Reviews·Sotiria Boukouvala, Giannoulis Fakis
Jul 11, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jason M WalravenDavid W Hein
Apr 20, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Verónica Ramírez-Alcántara, Marshall H Montrose
Aug 7, 2003·Chemico-biological Interactions·Charlene A McQueenMartin A Philbert

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