Arylamine N-acetyltransferase (NAT2) gene mutations in children with allergic diseases

Clinical Pharmacology and Therapeutics
E ZielińskaG Rebowski

Abstract

The overrepresentation of phenotypically slow acetylators among patients with atopic allergy has been reported in previous studies. The N-acetyltransferase coding gene has not yet been investigated in allergic diseases. This study was designed to determine the differences in the distribution of mutation frequency and genotypes that encode normal and defective activity of N-acetyltransferase in children with atopic allergies compared with healthy children. In 56 children with documented inhalational, food, or mixed allergies and in 100 healthy control children with no clinical or laboratory signs of allergy, the genotype coding for N-acetyltransferase was identified by means of the polymerase chain reaction followed by analysis of restriction fragment length polymorphism. Nucleotide transitions in the following positions were investigated: 481 C-->T, 590 G-->A, 803 A-->G, and 857 G-->A, which enabled the identification of six genotypes, including the wild-type (wt) allele, and 16 genotypes, including mutated alleles (homozygotic and herterozygotic). The statistical analysis showed significant differences in the distribution of the frequency of the occurrence of mutated alleles and genotypes between the two groups of children. In...Continue Reading

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Citations

Jun 27, 2012·Genetic Testing and Molecular Biomarkers·Muna K OqalYacoub M Irshaid
Oct 24, 2009·Current Opinion in Pediatrics·Xiumei HongXiaobin Wang
Mar 15, 2006·International Journal of Dermatology·Muradiye NacakA Sukru Aynacioglu
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Jul 18, 2009·Archives of Medical Research·Andrzej PawlikBarbara Gawronska-Szklarz

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