Arylanthranilodinitriles: a new biaryl class of antileishmanial agents

Bioorganic & Medicinal Chemistry Letters
Fateh V SinghAtul Goel

Abstract

A series of anthranilodinitrile-based biaryls were synthesized and evaluated in vitro against extracellular promastigotes and intracellular amastigotes of Leishmania donovani. Among various screened compounds, a biaryl with trifluoromethyl group 5f showed 83% inhibition against promastigotes and 70% inhibition against amastigotes of L. donovani at 8 and 20microg/mL concentrations, respectively.

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Citations

Feb 22, 2012·Acta Crystallographica. Section E, Structure Reports Online·Xuan LiuJiarong Li
Mar 18, 2008·The Journal of Organic Chemistry·Chenyi YiSilvio Decurtins
May 3, 2019·The Journal of Organic Chemistry·Xiangmeng ChenChau Ming So
Jan 29, 2008·Journal of Medicinal Chemistry·Theodora CalogeropoulouEffie Scoulica

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