Arylsulfatase A activity of urine in patients with various genitourinary tract disorders

Clinica Chimica Acta; International Journal of Clinical Chemistry
A MaruI Tsuji

Abstract

Arylsulfatase A activity was measured in urine from patients with various genitourinary tract disorders such as bladder tumor and inflammation. No significant difference in enzyme activity was found between normal and affected urine on the basis of either the volume or protein content of urine, a finding which differed from previous results. However, it was demonstrated that urine from affected patients was more labile to heat treatment in comparison with the control. Upon pretreatment of urine arylsulfatase A at 62.5 degrees C for 10 min, an average of 57% of the original activity was lost in samples from patients with bladder tumor, 58% in those with testicular tumor and 62% in cystitis and urethritis, respectively, while the enzyme activity in the control urine lost only 27% with similar heat treatment. These results were statistically significant with p < 0.001. The arylsulfatase A from patients with advanced bladder tumors demonstrated the presence of a variant form (pI 5.3) which was not detected in normal urine. This variant of arylsulfatase A was also demonstrated in nephrostomy urine from patients with congenital obstruction of the pelvi-ureteric junction.

References

Jan 3, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·L E Posey, L R Morgan
Aug 27, 1971·Biochimica Et Biophysica Acta·O Vesterberg
Apr 27, 1971·Biochimica Et Biophysica Acta·E NeuweltP Kohler
Jan 31, 1972·Biochemical and Biophysical Research Communications·J L Breslow, H R Sloan
Aug 28, 1972·Biochimica Et Biophysica Acta·K Stinshoff
Mar 25, 1968·Biochimica Et Biophysica Acta·E Mehl, H Jatzkewitz
Dec 1, 1957·Clinica Chimica Acta; International Journal of Clinical Chemistry·L M DZIALOSZYNSKI
Feb 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·J H AUSTIN
May 1, 1959·Clinica Chimica Acta; International Journal of Clinical Chemistry·H BAUMB SPENCER

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Citations

Apr 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Menna-PerperP Manowitz
Dec 31, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·P LaidlerJ Silberring
Jan 1, 1988·Clinical Biochemistry·J ArenasI Santos

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