PMID: 1212650Dec 11, 1975Paper

Arylsulfatse B in colorectal cancer

Cancer
L R MorganW R Meeker

Abstract

Arylsulfatase B activity has been determined in 24-hour urine samples from 243 patients with colorectal cancer. Elevated activity of the enzyme was obsereved in 172 out of 243 (71%) patients. Employing Dukes' modified classification of colorectal cancer, urine arylsulfatase B activity was elevated in Dukes' A lesions-1/8 (12%), Dukes' B lesions-24/43 (55%). Dukes' C lesions-89/111 (80%), and Dukes' D lesions-66/81 (82%). Arylsulfatase B activity in urine, when elevated, may be used to follow response to therapy since in those patients with elevated urine arylsulfatase B values who subsequently responded to therapy, the enzyme values became or approached normal. Urine arylsulfatase B activity also correlated with plasma carcinoembryonal antigen (CEA) as a diagnostic indicator of colorectal cancer in 33/46 (71%) patients. In contrast to the urinary findings, arylsulfatase B activity in tumor tissue was elevated in only 24% (27/110) of the specimens of colorectal cancer. It was also found that in a group of 55 patients treated with 5-fluorouracil, all of the 13 patients that showed objective response to therapy had activities of arylsulfatase B in the tumor tissue within the normal range for large bowel mucosa. Nevertheless, 22 to...Continue Reading

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Citations

Jan 1, 1978·CRC Critical Reviews in Clinical Laboratory Sciences·S F Markel
Jun 1, 1986·British Journal of Urology·M M el-Sharabasy, I el-Dosoky
Dec 18, 2014·Journal of Diabetes and Metabolic Disorders·Rima Samarji, Mahmoud Balbaa
Jan 1, 1976·Journal of Surgical Oncology·M M Copeland
Dec 1, 1979·Cancer·M G BrattainM Marks
Nov 1, 1977·Cancer·P Sherlock, S J Winawer
Jan 15, 2008·International Journal of Colorectal Disease·Malgorzata MatusiewiczTeresa Banas
Feb 1, 1984·Experimental and Molecular Pathology·M HiguchiW L Epstein
Oct 1, 1990·Clinical Biochemistry·M K Schwartz
Dec 1, 1979·Clinical Biochemistry·E Schmidt
Jul 14, 2005·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yildiz Oner-IyidoğanZeynep Ozbek-Kir

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