PMID: 11331534May 2, 2001Paper

As the gut ages: timetables for aging of innervation vary by organ in the Fischer 344 rat

The Journal of Comparative Neurology
R J Phillips, T L Powley

Abstract

To explore the effects of aging on the vagal innervation of the gastrointestinal (GI) tract, male Fischer 344 rats at 3 and 24 months of age were injected in the left nodose ganglion with 3 microl of either 4% wheat germ agglutinin-horseradish peroxidase (to label sensory endings) or 1% cholera toxin subunit B-horseradish peroxidase (to label motor endings). The stomach and duodenum were prepared as wholemounts and processed with tetramethyl benzidine. In addition, to study age-related changes in the myenteric plexus, the stomachs, small intestines, and large intestines from 3-, 12-, 21-, 24- and 27-month-old rats were prepared as wholemounts and processed with Cuprolinic Blue (to stain the neurons). Vagal afferent endings, motor terminal profiles, and myenteric neurons were counted and mapped with a sampling grid. In the stomach, both the vagal and myenteric innervation were stable between the ages of 3 and 24 months; however, a decrease in the number of myenteric neurons in the forestomach was noted at 27 months. In the small and large intestines, myenteric cell loss occurred by 12 months of age, progressed with age, and appeared to be governed by several general principles: (1) the rate of cell loss was organ-specific, with ...Continue Reading

References

Feb 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M M Mesulam
Jan 1, 1992·Clinical Neurology and Neurosurgery·D F Swaab
Aug 1, 1992·The Journal of Comparative Neurology·E A Fox, T L Powley
Oct 1, 1992·Digestive Diseases and Sciences·J L Madsen
May 1, 1991·Journal of the Autonomic Nervous System·T NaraS Hamano
Feb 15, 1990·The New England Journal of Medicine·R D Shamburek, J T Farrar
Sep 1, 1987·Journal of Neuroscience Methods·E A HeinickeJ Wijsman
Jan 1, 1989·Advances in Experimental Medicine and Biology·J KoistinahoA Hervonen
Jun 1, 1989·Gastroenterology·G Gabella
Nov 1, 1988·Journal of the Autonomic Nervous System·R M Santer, D M Baker
Feb 1, 1988·Mechanisms of Ageing and Development·D M Baker, R M Santer
Jan 1, 1969·Gerontologia Clinica·J C Brocklehurst, M Y Khan
May 1, 1984·Journal of the American Geriatrics Society·S Anuras, V Loening-Baucke
Aug 1, 1984·Clinical Science·M HorowitzD J Shearman
Apr 1, 1983·Digestive Diseases and Sciences·J G MooreF L Datz
Sep 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W W Pugh, M Kalia
Oct 10, 1980·Science·D Purves, J W Lichtman
Nov 1, 1980·Journal of Gerontology·G J Kelliher, S T Conahan
Nov 1, 1993·Journal of Neurophysiology·S M Johnson, R B Felder
Apr 1, 1993·Cell and Tissue Research·H M YoungC J Kandiah
Aug 27, 1996·Journal of the Autonomic Nervous System·N Soltanpour, R M Santer

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Citations

Oct 14, 2004·Anatomy and Embryology·Robert J PhillipsTerry L Powley
Oct 27, 2012·Biogerontology·Sara FidalgoShona H Wood
Dec 15, 2011·Journal of Physiology and Biochemistry·P PascuaP J Camello
Feb 6, 2004·Journal of Neuroscience Methods·Robert J PhillipsTerry L Powley
Jul 25, 2003·Autonomic Neuroscience : Basic & Clinical·Robert J PhillipsTerry L Powley
Dec 28, 2007·Proceedings of the National Academy of Sciences of the United States of America·M J FarrellG F Egan
Jan 27, 2005·Journal of Paediatrics and Child Health·B R SouthwellJ M Hutson
Jan 17, 2012·Journal of Clinical Biochemistry and Nutrition·Hidekazu SuzukiToshifumi Hibi
Feb 6, 2013·World Journal of Gastroenterology : WJG·Kathy J LePard, Joseph Cellini
Jul 23, 2009·Nutritional Neuroscience·Fernando Carlos de Sousa, Marcílio Hubner de Miranda Neto
Jan 18, 2014·Experimental Gerontology·João Paulo Ferreira SchoffenMaria Raquel Marçal Natali
Mar 23, 2012·Autonomic Neuroscience : Basic & Clinical·Robert J Phillips, Terry L Powley
Feb 22, 2012·Autonomic Neuroscience : Basic & Clinical·Gisele da Silva PortoRenata de Britto Mari
Nov 6, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Eliane Florencio GamaRomeu Rodrigues de Souza
Aug 12, 2009·Experimental Neurology·Robert J PhillipsTerry L Powley
Sep 8, 2009·Autonomic Neuroscience : Basic & Clinical·Michael S KasparekMichael G Sarr
Aug 12, 2009·Autonomic Neuroscience : Basic & Clinical·Robert J PhillipsTerry L Powley
Jul 15, 2009·Neurobiology of Disease·Robert E DroletJ Timothy Greenamyre
Apr 1, 2008·PET Clinics·Rakesh KumarAbass Alavi
Dec 6, 2008·Journal of Neuroscience Methods·Gary C WalterTerry L Powley
Oct 10, 2007·Clinics in Geriatric Medicine·Paul KuoMichael Horowitz
Sep 13, 2007·Journal of Pediatric Surgery·Tamas CserniPrem Puri
Jun 1, 2007·Autonomic Neuroscience : Basic & Clinical·Robert J Phillips, Terry L Powley
Jan 27, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Raquel AbaloM Isabel Martín
Jun 23, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C J PeckB R Southwell
Aug 31, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M D Gershon, M-T Liu
Mar 23, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C H V Hoyle, M J Saffrey
Jul 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R J PhillipsT L Powley
Feb 27, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Robert J PhillipsTerry L Powley
Mar 23, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·P P K M GamageM J Saffrey
Jun 10, 2010·The Journal of Comparative Neurology·Michelle C Murphy, Edward A Fox
May 3, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C WangM J Saffrey
Oct 21, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B R SouthwellJ M Hutson
Nov 27, 2004·Mechanisms of Ageing and Development·M Jill Saffrey
Aug 7, 2004·Autonomic Neuroscience : Basic & Clinical·Menachem HananiHerbert R Freund
Jun 24, 2006·Neurobiology of Aging·Robert J PhillipsTerry L Powley

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