ASAS40 and ASDAS clinical responses in the ABILITY-1 clinical trial translate to meaningful improvements in physical function, health-related quality of life and work productivity in patients with non-radiographic axial spondyloarthritis

Rheumatology
Désirée M F van der HeijdeYanjun Bao

Abstract

To assess the impact of achieving Assessment in SpondyloArthritis international Society 40% (ASAS40) response or an Ankylosing Spondylitis Disease Activity Score inactive disease (ASDAS-ID) state on patient-reported outcomes (PROs) among patients with non-radiographic axial SpA (nr-axSpA). Data are from ABILITY-1, a phase 3 trial of adalimumab vs placebo in nr-axSpA patients. PROs included the HAQ for Spondyloarthropathies (HAQ-S), 36-item Short Form Health Survey (SF-36) physical component summary (PCS) score and Work Productivity and Activity Impairment Questionnaire. Patients were grouped by clinical response using ASAS40 response and ASDAS disease states at week 12. Changes in PROs from baseline to week 12 were compared between groups using analysis of covariance with adjustment for baseline scores. At week 12, 47 of 179 patients were ASAS40 responders and 26 of 176 patients achieved ASDAS-ID (ASDAS <1.3). Compared with non-responders (n = 132), ASAS40 responders (n = 47) had a significantly greater improvement in mean HAQ-S (-0.65 vs -0.05, P < 0.0001), SF-36 PCS (12.4 vs 0.7, P < 0.0001), presenteeism (-24.7 vs -2.2, P < 0.0001), overall work impairment (-23.9 vs -2.5, P < 0.0001) and activity impairment (-33.5 vs -0.9, P...Continue Reading

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Citations

Jan 15, 2017·Annals of the Rheumatic Diseases·Désirée van der HeijdeJürgen Braun
Aug 6, 2017·Clinical Reviews in Allergy & Immunology·Ennio LubranoFabio Massimo Perrotta
May 16, 2019·Current Opinion in Rheumatology·Pedro M Machado, Atul Deodhar
Jul 29, 2020·Current Rheumatology Reports·Elena Nikiphorou, Sofia Ramiro
Sep 15, 2017·Cost Effectiveness and Resource Allocation : C/E·Stephanie HarvardAslam Anis
Aug 25, 2017·Therapeutic Advances in Musculoskeletal Disease·Valeria Rios Rodriguez, Denis Poddubnyy
Dec 31, 2016·Rheumatology International·Andrew KeatTamara Everiss
Sep 1, 2018·Rheumatology International·Fernando Andres SommerfleckGustavo Citera
Oct 1, 2019·Rheumatic Diseases Clinics of North America·Elena Nikiphorou, Xenofon Baraliakos
Oct 15, 2020·Rheumatology·Xabier MichelenaHelena Marzo-Ortega
Dec 22, 2020·Therapeutic Advances in Musculoskeletal Disease·Katharina MeierKamran Ghoreschi
Jun 28, 2021·Rheumatology·Esther BeckersAstrid van Tubergen

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