Asbestos induces aberrant crypt foci in the colon of rats

Cancer Letters
D E CorpetI Goubet

Abstract

The carcinogenicity of asbestos to the gut is controversial. The aberrant crypt focus (ACF) assay is proposed as a test for colon carcinogens. We have scored ACF in the colon of rats and mice, one month after per os gavages with suspensions of asbestos fibers. Crocidolite asbestos induced ACF in the colon of rats in two independent experiments (P = 0.02 and P < 0.01 compared to controls given water), and was ten times less effective than the carcinogen azoxymethane. Chrysotile asbestos also induced ACF in rats. Neither crocidolite nor chrysotile induced ACF in mice. The data suggest that ingested asbestos may be carcinogenic to the colon.

References

Oct 1, 1992·Carcinogenesis·S A Stopera, R P Bird
Dec 18, 1991·Journal of the National Cancer Institute·A I NeugutC Fenoglio-Preiser

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Citations

Oct 15, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H EnzmannG M Williams
May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Melisa Bunderson-SchelvanAndrij Holian
Apr 25, 2015·Annals of Occupational and Environmental Medicine·Soo-Hong ParkJong-Eun Kim
Mar 10, 2017·Expert Review of Gastroenterology & Hepatology·Agostino Di Ciaula
Sep 24, 2020·Reviews on Environmental Health·Thales J ChengErnest S Fung

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