PMID: 8944725Nov 1, 1996Paper

Asbestos induces apoptosis in human alveolar macrophages

The American Journal of Physiology
R F HamiltonA Holian

Abstract

Asbestos refers to a group of fibrous minerals implicated in the development of several lung diseases, including fibrosis (asbestosis), cancer, and malignant mesothelioma. Although major health risks exist in occupationally exposed individuals, low-level exposures of asbestos may still contribute to health problems. The mechanism by which asbestos causes lung disease is not clearly understood but has been proposed to involve the alveolar macrophage (AM). We propose that asbestos induces apoptosis of AM, resulting in the development of an inflammatory state. In this study, we examined two forms of asbestos, chrysotile (CHR) and crocidolite (CRO), along with a control fiber, wollastonite (WOL), to characterize their relative cytotoxicity and ability to stimulate apoptosis in vitro. AM were cultured for 24 h with these particulates and examined for cell viability (trypan blue exclusion) and apoptosis (morphology, levels of cytosolic oligonucleosomal DNA fragments, and DNA ladder). In the absence of a decrease in cell viability, both CHR and CRO produced changes in cell morphology consistent with apoptosis. In addition, levels of cytoplasmic oligonucleosomal DNA (Cell Death Detection enzyme-linked immunosorbent assay) were signific...Continue Reading

Citations

Apr 5, 2003·Environmental Health Perspectives·Masato MatsuokaYasuo Morimoto
Nov 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·K AoshibaA Nagai
Jun 19, 2008·Environmental Health Perspectives·Glinda S CooperNoel R Rose
May 26, 2018·American Journal of Industrial Medicine·Alison ReidJean Pfau
May 30, 2003·Experimental Biology and Medicine·Daya Upadhyay, David W Kamp
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·Maureen R GwinnVal Vallyathan
Jan 11, 2018·International Journal of Environmental Research and Public Health·Violetta BorelliGiuliano Zabucchi
Dec 24, 1997·Environmental Health Perspectives·A HolianR F Hamilton
Jun 17, 2008·American Journal of Respiratory Cell and Molecular Biology·Renée M GilbertiDavid A Knecht
Jan 3, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·H M ShenC N Ong
Jan 1, 2005·Environmental Health Perspectives·Jean C PfauElizabeth A Putnam
Feb 4, 2010·Journal of Occupational Health·Yuichiro KudoYoshiharu Aizawa
May 31, 2014·Autoimmune Diseases·Jean C PfauCurtis W Noonan
Sep 20, 2018·Journal of Toxicology and Environmental Health. Part a·Jean C PfauMarvin J Fritzler
Aug 3, 2006·Environmental Health Perspectives·Curtis W NoonanMichael R Spence
Mar 7, 2021·Toxicology·Alessandro F GualtieriDario Di Giuseppe

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