PMID: 8592175Jan 1, 1995Paper

Ascending central nervous spreading of a spinal astrocytoma

Journal of Neuro-oncology
D ClausB Volk

Abstract

A 43-year-old man died from the complications of astrocytoma metastasis. He first noticed symptoms of a lumbar disc prolapse in 1979. In 1987 a pilocytic astrocytoma (grade I) of the spinal cauda was removed. In 1989 a tumor recidivation at the same site was partially removed. Histology showed a grade II astrocytoma. Two months later the patient developed symptoms of increased intracerebral pressure. CSF cytology showed polymorphic giant tumor cells with hyperchromatic nuclei and a glioblastoma of the cerebral ventricles was diagnosed. The patient died from cardiovascular complications. The post-mortem investigation revealed an astrocytoma of the conus medullaris with an anaplastic ventral area (grade IV). This area was inaccessible to the biopsy. It is believed that tumor metastases from anaplastic parts spread along the spinal cord and brainstem and finally invaded the brain and cerebral ventricles.

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Citations

Dec 5, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Shelly X BianDavid R Grosshans
Sep 21, 2000·Clinical Neurology and Neurosurgery·A M ScarrowW C Welch
Aug 8, 2014·Surgical Neurology International·Stephanus ViljoenPatricia A Kirby
Nov 24, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A V KulkarniJ M Drake
Jun 24, 2010·Neurocirugía·A Otero-RodríguezT Zamora-Martínez
Nov 7, 2006·Journal of Neuropathology and Experimental Neurology·David T W JonesV Peter Collins
Jul 18, 2009·Journal of Korean Neurosurgical Society·Se Youn JangJohn G Frazee
Dec 31, 1997·Clinical Nuclear Medicine·B WoeslerO Schober

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