Ascending pathways from the nucleus of the solitary tract to the subfornical organ in the rat

Brain Research
J TanakaM Nomura

Abstract

Electrical stimulation of the nucleus of the solitary tract (NTS) produced orthodromic excitation (n = 28, 15%) and inhibition (n = 6, 4%) of the activity of neurons in the subfornical organ (SFO) in male rats under urethane anesthesia. Almost all (n = 26) of the excitatory responses (n = 28) were blocked by microiontophoretically applied phentolamine, an alpha-adrenergic antagonist, but not by timolol, a beta-adrenergic antagonist. In contrast, the inhibitory response of all the neurons (n = 6) tested was not affected by either phentolamine or timolol. Approximately two-third (n = 19) of SFO neurons that demonstrated the excitatory response to NTS stimulation exhibited an increase in neuronal activity in response to hemorrhage (10 ml/kg b.w.t.). Hemorrhage did not cause any change in the activity of all the neurons that demonstrated the inhibitory response to NTS stimulation. These results suggest that the excitatory pathways from the NTS to the SFO may transmit the peripheral baroreceptor information through alpha-adrenoreceptor mechanisms.

References

Jul 1, 1984·Brain Research Bulletin·M L MangiapaneW F Ganong
Jan 1, 1995·Brain Research Bulletin·G B Gu, G Ju

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Citations

Dec 23, 2003·Regulatory Peptides·G Trevor Cottrell, Alastair V Ferguson
Oct 16, 2002·Neuroscience Letters·Junichi TanakaMasahiko Nomura
Nov 9, 2002·Autonomic Neuroscience : Basic & Clinical·Junichi TanakaMasahiko Nomura
Aug 26, 1998·Experimental Neurology·J TanakaM Nomura
Oct 6, 2005·Journal of the Society for Gynecologic Investigation·Mostafa A El-HaddadMichael G Ross
Feb 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eiko HondaKiyotoshi Inenaga
Oct 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Charles HindmarchAlastair V Ferguson
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Robert M SilvaRichard J Bodnar

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