Ascertainment and verification of end-stage renal disease and end-stage liver disease in the north american AIDS cohort collaboration on research and design

AIDS Research and Treatment
Mari KitahataRichard Moore

Abstract

The burden of HIV disease has shifted from traditional AIDS-defining illnesses to serious non-AIDS-defining comorbid conditions. Research aimed at improving HIV-related comorbid disease outcomes requires well-defined, verified clinical endpoints. We developed methods to ascertain and verify end-stage renal disease (ESRD) and end-stage liver disease (ESLD) and validated screening algorithms within the largest HIV cohort collaboration in North America (NA-ACCORD). Individuals who screened positive among all participants in twelve cohorts enrolled between January 1996 and December 2009 underwent medical record review to verify incident ESRD or ESLD using standardized protocols. We randomly sampled 6% of contributing cohorts to determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of ESLD and ESRD screening algorithms in a validation subcohort. Among 43,433 patients screened for ESRD, 822 screened positive of which 620 met clinical criteria for ESRD. The algorithm had 100% sensitivity, 99% specificity, 82% PPV, and 100% NPV for ESRD. Among 41,463 patients screened for ESLD, 2,024 screened positive of which 645 met diagnostic criteria for ESLD. The algorithm had 100% sensitivity...Continue Reading

References

Aug 5, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C T StaplesD Dudas
Dec 2, 1999·Journal of Clinical Epidemiology·W E BarlowS Izumi
Oct 13, 2001·The Journal of Infectious Diseases·J J GoedertUNKNOWN Multicenter Hemophilia Cohort Study
Feb 8, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth E ShermanNatasa Rajicic
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
May 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samir K GuptaLynda A Szczech
Dec 6, 2005·AIDS·Nicolás MerchanteUNKNOWN Grupo Andaluz para el Estudio de las Enfermedades Infecciosas
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Richard K SterlingUNKNOWN APRICOT Clinical Investigators
Aug 1, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Frank J PalellaUNKNOWN HIV Outpatient Study Investigators
Nov 14, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Geetanjali ChanderRichard D Moore
Jan 11, 2007·International Journal of Epidemiology·Stephen J GangeRichard D Moore
Jan 18, 2007·Annals of Internal Medicine·Nicolai LohseNiels Obel
Apr 26, 2007·The Journal of Clinical Endocrinology and Metabolism·Virginia A TriantSteven K Grinspoon
Aug 11, 2007·Annals of Epidemiology·Jacques BaillargeonBen G Raimer
Sep 7, 2007·Kidney International·A I ChoiA M O'Hare
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Andy I ChoiAnn M O'Hare
Feb 12, 2008·International Journal of Epidemiology·Mari M KitahataMichael S Saag
Mar 28, 2008·HIV Medicine·G ChanderUNKNOWN HIV Research Network
Apr 7, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·M V RagniQ Dang
Apr 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Judith TsuiLynda Szczech
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Sep 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Javier MurillasUNKNOWN ESLD-HIV Working Group Investigators
Oct 23, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elena LosinaKenneth A Freedberg
Jun 4, 2010·Kidney International·Andy I ChoiMichael G Shlipak
Sep 3, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Joan Carles TrullasUNKNOWN EuroSIDA Investigators
Oct 27, 2010·HIV Clinical Trials·Alan R Lifson INSIGHT Study Group
Feb 19, 2011·AIDS·Julia ThorpeUNKNOWN Canadian Co-infection Cohort Study (CTN222)
Feb 19, 2011·AIDS·María López-DiéguezUNKNOWN GESIDA 37/03-FIPSE 36465/03-NEAT IG5 Study Group
Dec 31, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Vasantha JotwaniMichael G Shlipak
Jul 24, 2012·JAMA : the Journal of the American Medical Association·Berkeley N LimketkaiMark S Sulkowski
Jun 6, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth L YanikJoseph J Eron
Aug 2, 2013·The Journal of Infectious Diseases·Gregory M LucasUNKNOWN NA-ACCORD of the IeDEA
Mar 13, 2014·American Journal of Epidemiology·H M CraneUNKNOWN Centers for AIDS Research Network of Integrated Clinical Systems Cohort Investigators

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Citations

Aug 11, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marina B KleinUNKNOWN North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA
May 13, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A D MuzaaleD L Segev
Nov 18, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Cherise WongUNKNOWN North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)
Nov 4, 2021·Pharmacoepidemiology and Drug Safety·Jim YoungUNKNOWN North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA

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Methods Mentioned

BETA
biopsy

Software Mentioned

NA
CNICS
ACCORD

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