Ascertainment of Aspirin Exposure Using Structured and Unstructured Large-scale Electronic Health Record Data.

Medical Care
Ranier BustamanteLin Liu

Abstract

Aspirin impacts risk for important outcomes such as cancer, cardiovascular disease, and gastrointestinal bleeding. However, ascertaining exposure to medications available both by prescription and over-the-counter such as aspirin for research and quality improvement purposes is a challenge. Develop and validate a strategy for ascertaining aspirin exposure, utilizing a combination of structured and unstructured data. This is a retrospective cohort study. In total, 1,869,439 Veterans who underwent usual care colonoscopy 1999-2014 within the Department of Veterans Affairs. Aspirin exposure and dose were obtained from an ascertainment strategy combining query of structured medication records available in electronic health record databases and unstructured data extracted from free-text progress notes. Prevalence of any aspirin exposure and dose-specific exposure were estimated. Positive predictive value and negative predictive value were used to assess strategy performance, using manual chart review as the reference standard. Our combined strategy for ascertaining aspirin exposure using structured and unstructured data reached a positive predictive value and negative predictive value of 99.2% and 97.5% for any exposure, and 92.6% and...Continue Reading

References

Jan 2, 2003·Journal of the American Medical Informatics Association : JAMIA·John M FiskPrakash Nadkarni
Mar 7, 2003·The New England Journal of Medicine·Thomas F Imperiale
Nov 17, 2007·Gastroenterology·Andrew T ChanCharles S Fuchs
Nov 16, 2011·Cancer Prevention Research·Andrew T ChanJohn A Baron
Jun 27, 2012·Journal of the American Medical Informatics Association : JAMIA·Nicole Gray Weiskopf, Chunhua Weng
Nov 21, 2012·The American Journal of Medicine·Divey ManochaUma K Murthy
Jul 28, 2013·British Journal of Cancer·F JonssonY Pawitan
Aug 16, 2014·Yearbook of Medical Informatics·M K RossL Ohno-Machado
Mar 25, 2016·Journal of the American Heart Association·S Marlene GrenonBeth E Cohen
Aug 27, 2016·Journal of the American College of Cardiology·Paola Patrignani, Carlo Patrono
Apr 19, 2017·Journal of the American Medical Informatics Association : JAMIA·David S CarrellAteev Mehrotra
Jun 5, 2017·The Medical Clinics of North America·Ilana B Richman, Douglas K Owens

❮ Previous
Next ❯

Citations

Sep 17, 2019·BMJ Open Gastroenterology·Joshua DembSamir Gupta
Nov 15, 2019·Clinical and Translational Gastroenterology·Joshua DembSamir Gupta
Mar 9, 2021·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Aline Tsuma Gaedke NomuraMiriam de Abreu Almeida
Nov 27, 2019·Clinical and Translational Gastroenterology·Joshua DembSamir Gupta
Jan 14, 2020·Gastroenterology·Eric E LowSamir Gupta
May 19, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Taniqua T IngolSarah A Keim
Jul 31, 2021·Journal of Biomedical Informatics·Lin LiuSamir Gupta

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SQL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.