Ascidian Toxins with Potential for Drug Development

Marine Drugs
Dianne J Watters

Abstract

Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of these natural products are not produced by the ascidians themselves, rather by their associated symbionts. This review will focus mainly on the mechanism of action of important classes of cytotoxic molecules isolated from ascidians. These toxins affect DNA transcription, protein translation, drug efflux pumps, signaling pathways and the cytoskeleton. Two ascidian compounds have already found applications in the treatment of cancer and others are being investigated for their potential in cancer, neurodegenerative and other diseases.

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Citations

Feb 7, 2020·Expert Opinion on Drug Discovery·Kevin Andrew StuartRuAngelie Edrada-Ebel
Jul 11, 2020·Biomolecules·Gennaro RiccioChiara Lauritano
May 31, 2020·International Journal of Biological Macromolecules·Ruiwei YeLiang Xiao
Nov 7, 2020·European Journal of Medicinal Chemistry·Mariana C AlmeidaEmília Sousa
May 28, 2021·Current Microbiology·Nadarajan VijuSathianeson Satheesh
Jun 3, 2021·Marine Drugs·Chatragadda RameshLaurent Dufossé
Aug 28, 2021·Biomedicines·Rodion KhotimchenkoYuri Khotimchenko

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Methods Mentioned

BETA
xenograft
immunoprecipitation
X-ray
electron microscopy

Software Mentioned

CADD
PharmaMar

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