PMID: 11345143May 10, 2001Paper

Ascites of rat experimental model of severe acute pancreatitis induces lung injury

Pancreas
M FujitaT Shimosegawa

Abstract

The molecular mechanisms that lead from acute pancreatitis (AP) to multiple organ failure remain to be clarified. We previously reported that ascitic fluids from a rat model of severe acute pancreatitis (pancreatitis-associated ascitic fluids, PAAF) transcriptionally activated endothelial cells and leukocytes in vitro. To clarify the role of ascitic fluids on the development of multiple organ failure in AP, we examined the effects of PAAF on the prognosis and immunohistologic findings in cerulein pancreatitis, an experimental model of mild pancreatitis in vivo. Intraperitoneal injection of PAAF decreased the survival rates in a dose-dependent manner. Histologically, destruction of vessels, alveolar septal thickening, interstitial hypertrophy, and infiltration of inflammatory cells were prominent in the lung of PAAF-injected rats. Transcription factor, nuclear factor KB (NF-kappaB) was activated and the mRNA levels of tumor necrosis factor-alpha and interleukin-1beta were increased in the lung of the PAAF-injected rats. The permeability index assessed by Evans blue assay and the lung myeloperoxidase activity levels were significantly higher in the PAAF-injected rats than in controls. Inhibition of NF-kappaB ameliorated the histo...Continue Reading

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Citations

Jul 18, 2006·Intensive Care Medicine·Denis R MorelCatherine M Pastor
Mar 27, 2003·Pancreas·Ana Maria de Mendonça CoelhoEmilio Elias Abdo
Oct 19, 2002·Current Opinion in Critical Care·Conor J ShieldsH Paul Redmond
Jan 7, 2014·Internal Medicine·Kazuyuki MatsumotoKazuhide Yamamoto
Aug 24, 2010·World Journal of Gastroenterology : WJG·Pratima Shrivastava, Madhav Bhatia
Jun 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianbo LiZhirong Zhang
Sep 20, 2007·International Journal of Experimental Pathology·Manuel A MansoIsabel De Dios
Apr 28, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Hayam AteyyaNagla A El-Sherbeeny
Mar 3, 2005·World Journal of Gastroenterology : WJG·Tamas LetohaBotond Penke
May 3, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Salvador PérezJuan Sastre

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