Ascitic fluid adenosine deaminase insensitivity in detecting tuberculous peritonitis in the United States

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
D J HillebrandG P Rynders

Abstract

Tuberculous peritonitis, although common in Third World countries, remains an uncommon cause of ascites in the United States. Ascitic fluid adenosine deaminase (ADA) activity has been proposed as a useful diagnostic test. The aim of this retrospective study was to determine the clinical utility of ascitic fluid ADA activity in diagnosing tuberculous peritonitis in a U.S. patient population. A total of 368 ascitic fluid specimens from a well-characterized ascitic fluid bank, including tuberculous peritonitis (n = 7), tuberculous peritonitis in the setting of cirrhosis (n = 10), and consecutive specimens of widely varied etiologies (n = 351) were analyzed for ADA activity by ultraviolet spectrophotometry at 265 nm. The overall sensitivity of the ADA determination in diagnosing tuberculous peritonitis was only 58.8%, and the specificity was 95.4%. The accuracy of ADA determination (93.8%) compared favorably with that of the common ascitic fluid tests of white blood cell (WBC) count (>500/mm3), total protein (>2.5 g/dL), and combined WBC count and total protein (45.8%, 74.4%, and 81.3%, respectively). However, ADA was only 30% sensitive in detecting tuberculous peritonitis in the setting of cirrhosis, and cirrhosis was present in 5...Continue Reading

Citations

Jun 6, 1998·The New England Journal of Medicine·J S CzachorJ R Miller
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Castellote
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M M LeungC A Marietta
Jul 30, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kai Ming ChowCheuk Chun Szeto
Jan 15, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tai Nin ChauYiu Wing Ho
Sep 18, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S RasheedP J McDonald
Feb 2, 2008·Journal of Medical Case Reports·Yilin VogelBernhard F Henning
Jun 12, 2013·Emerging Infectious Diseases·Kevin L ArdSerena P Koenig
Dec 17, 2008·World Journal of Gastroenterology : WJG·Gönül DinlerAyhan Gazi Kalayci
Jan 27, 2010·World Journal of Gastroenterology : WJG·Francesco BarbagalloGaetano La Greca
Jun 22, 2012·World Journal of Gastroenterology : WJG·Seung Joo KangIn Sung Song
Sep 2, 2011·World Journal of Surgery·Kwang Dae HongHong Young Moon
Mar 30, 2007·Digestive Diseases and Sciences·Angela McGibbonSander Veldhuyzen van Zanten
Aug 1, 2009·Clinical Journal of Gastroenterology·Yuu ShimozumaMichio Imawari
Apr 6, 2005·Surgical Endoscopy·A A Al-Mulhim
May 19, 2017·Der Internist·A Hiseni-KamberiM Argirov
Nov 7, 2009·Chest·Amen SergewMarvin I Schwarz
Mar 19, 2014·Diagnostic Microbiology and Infectious Disease·Lin TaoHai-Xing Jiang
Mar 5, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruce A Runyon, UNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases (AASLD)
Aug 23, 2002·The American Journal of Gastroenterology·Andrés Cárdenas, Sanjiv Chopra
Jun 9, 2001·European Journal of Gastroenterology & Hepatology·K DemirY Cakaloglu
May 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bruce A Runyon, UNKNOWN AASLD Practice Guidelines Committee
Jul 12, 2018·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Aug 30, 2011·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hwa Mi KangKeun Ho Yang
Aug 31, 2006·Journal of Clinical Gastroenterology·Arnoldo RiquelmeLuz María Letelier
Dec 22, 1999·The American Journal of Gastroenterology·E FernándezS Riestra
Oct 30, 2008·Journal of Digestive Diseases·Orhan K PoyrazogluIbrahim H Bahcecioglu
Sep 2, 2009·Drugs·Fedja A Rochling, Rowen K Zetterman
Apr 14, 2010·Journal of Pediatric Gastroenterology and Nutrition·Faten TinsaSouad Bousnina
Sep 18, 2010·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Young Seok Kim
Oct 4, 2005·Alimentary Pharmacology & Therapeutics·F M Sanai, K I Bzeizi
Feb 15, 2019·Digestive Diseases and Sciences·Eric ArdolinoVilas R Patwardhan
Jun 5, 2012·World Journal of Hepatology·Chalermrat Bunchorntavakul, Disaya Chavalitdhamrong
Jun 28, 2019·Journal of Gastroenterology and Hepatology·Shenghua ZhuYuhu Song
Mar 23, 2018·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·M A OktanA Çelik
Dec 19, 2002·Journal of Clinical Gastroenterology·Ahmet Kemal GürbüzSükrü Yildirim
Mar 12, 2004·Nephrology·David W JohnsonPaul Snelling
Jul 11, 2014·BMJ Case Reports·Shelli FarhadianMerceditas S Villanueva
Jun 6, 1998·The New England Journal of Medicine·A Conde, J Marchena
Dec 17, 2008·Southern Medical Journal·Semaan KosseifiJay Mehta
Dec 17, 2011·Journal of Medical Microbiology·Mohammad A SalehAsmaa F Enein
Nov 10, 2004·World Journal of Gastroenterology : WJG·Ali UzunkoyMehmet Harma
Mar 29, 2014·Experimental and Therapeutic Medicine·Hai-Jun HuangZhuo-Chao Ren
May 8, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Ayako KumabeMasami Matsumura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.