Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma

Disease Models & Mechanisms
Luke A WylieAnna Philpott

Abstract

Neuroblastoma (NB), although rare, accounts for 15% of all paediatric cancer mortality. Unusual among cancers, NBs lack a consistent set of gene mutations and, excluding large-scale chromosomal rearrangements, the genome seems to be largely intact. Indeed, many interesting features of NB suggest that it has little in common with adult solid tumours but instead has characteristics of a developmental disorder. NB arises overwhelmingly in infants under 2 years of age during a specific window of development and, histologically, NB bears striking similarity to undifferentiated neuroblasts of the sympathetic nervous system, its likely cells of origin. Hence, NB could be considered a disease of development arising when neuroblasts of the sympathetic nervous system fail to undergo proper differentiation, but instead are maintained precociously as progenitors with the potential for acquiring further mutations eventually resulting in tumour formation. To explore this possibility, we require a robust and flexible developmental model to investigate the differentiation of NB's presumptive cell of origin. Here, we use Xenopus frog embryos to characterise the differentiation of anteroventral noradrenergic (AVNA) cells, cells derived from the ...Continue Reading

References

Jun 2, 1997·The EMBO Journal·W A WeissJ M Bishop
Jan 13, 1998·Nature Genetics·E M Southard-SmithW J Pavan
Mar 19, 1999·Biochemical and Biophysical Research Communications·H SöderholmS Påhlman
Dec 4, 2001·Mechanisms of Development·E Sonnenberg-RiethmacherD Riethmacher
Mar 4, 2003·Nature Reviews. Cancer·Garrett M Brodeur
Jun 7, 2003·Developmental Cell·Amy BellmeyerCarole LaBonne
Jul 10, 2003·Biochemical and Biophysical Research Communications·Yohko NakamuraShigeru Sakiyama
Jul 30, 2003·Developmental Biology·Stella M HonoréRoberto Mayor
Dec 25, 2004·Developmental Biology·Marthe J Howard
Sep 28, 2005·Neurochemical Research·Klaus UnsickerChaya Kalcheim
Jun 26, 2007·Lancet·John M MarisSusan L Cohn
Jul 12, 2007·The Biochemical Journal·Jonathan M D VosperAnna Philpott
Jul 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Damien ParlierEric J Bellefroid
Jun 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jan J MolenaarHuib N Caron
Jan 29, 2010·Nature·Thomas VierbuchenMarius Wernig
Jun 19, 2010·The New England Journal of Medicine·John M Maris
May 28, 2011·Nature·Zhiping P PangMarius Wernig
Nov 23, 2011·The European Journal of Neuroscience·Hermann Rohrer
Mar 24, 2012·Cancer Cell·Shizhen ZhuA Thomas Look
Oct 24, 2012·Proceedings of the National Academy of Sciences of the United States of America·Linda J ValentijnRogier Versteeg
Jan 22, 2013·Nature Genetics·Trevor J PughJohn M Maris
Sep 21, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julieann RaderJohn M Maris
May 6, 2014·Trends in Genetics : TIG·Laura J A Hardwick, Anna Philpott

❮ Previous
Next ❯

Citations

Apr 5, 2016·Annals of Neurology·Nancy RatnerNina F Schor
Oct 30, 2016·Acta Biochimica Et Biophysica Sinica·Zheying MinQinghua Tao
May 2, 2017·Oncogene·R R OlsenK W Freeman
May 4, 2018·Development·Nicholas E Baker, Nadean L Brown
Jul 19, 2016·Journal of Cellular Biochemistry·Peter E ZageJason M Shohet
May 16, 2018·Development·Roberta AzzarelliAnna Philpott
Sep 23, 2018·Biochemical Society Transactions·Laura J A HardwickAnna Philpott
Dec 13, 2018·Frontiers in Physiology·Laura J A Hardwick, Anna Philpott
Nov 16, 2018·Wellcome Open Research·Laura J A Hardwick, Anna Philpott
Feb 7, 2021·Science Advances·Vidyasagar KoduriWilliam G Kaelin
Dec 29, 2020·Genesis : the Journal of Genetics and Development·Cameron R T Exner, Helen Rankin Willsey

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

AVNA
R2

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cambridge Stem Cell Institute - Researcher Network

Cambridge Stem Cell Institute's mission is to transform human health through a deep understanding of stem cell biology. Follow this feed to stay up to date on research published in this group.