Ascorbic acid-A black hole of urine chemistry screening

Journal of Clinical Laboratory Analysis
Adriana UnicNada Vrkic

Abstract

Study was performed in order: (i) to assess the comparability of glucose, bilirubin, hemoglobin, leukocyte esterase, and protein; (ii) to assess accuracy of glucose, bilirubin, hemoglobin, leukocyte esterase, and protein; and (iii) to evaluate interference of ascorbic acid on the glucose, bilirubin, hemoglobin, and nitrite determination using 2 different dipsticks: iChem Velocity, Iris Diagnostics and Combur-10M, Roche Diagnostics. Random urine specimens were included in the study. Comparability, accuracy, and ascorbic acid interference testing were performed. Obtained results have shown almost perfect agreement for all parameters between 2 dipsticks in samples with negative ascorbic acid. Agreement in samples with positive ascorbic acid was not acceptable for bilirubin, protein, nitrite, and hemoglobin. Accuracy was not acceptable for hemoglobin and leukocyte esterase on both dipsticks. Ascorbic acid interference examination has shown that intensity of interference differs between dipsticks. Ascorbic acid interferes with glucose, hemoglobin, nitrite, and bilirubin at different concentrations causing false-negative results. Obtained results indicate that it is necessary to determine diagnostic accuracy of used dipstick in order...Continue Reading

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Citations

Oct 2, 2019·Annals of Clinical Biochemistry·Nora Nikolac GabajJelena Culej
Jan 14, 2021·Regional Anesthesia and Pain Medicine·Audrey DieuUNKNOWN PROSPECT Working Group of the European Society of Regional Anaesthesia and Pain Therapy (ESRA)

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