Ascorbic acid and pyridoxine in experimental anaphylaxis

Agents and Actions
R G Alvarez, M G Mesa

Abstract

Two vitamins, ascorbic acid (AA) and pyridoxine have been suggested by others as useful drugs for the treatment of bronchial asthma, although the views concerning AA or controversial. We have tested both vitamins in some models of histamine release and experimental anaphylaxis. AA does not inhibit mast cell degranulation induced by phospholipase A and histamine release from isolated rat mast cells induced by compound 48/80 or antigen (egg albumin). On the contrary, in the latter tests pyridoxine exerts inhibition in a range of concentrations from 10(-3)-10(-2) M. We conclude: 1. There is no experimental basis for considering ascorbic acid as a prophylactic antiasthmatic drug as is disodium cromoglycate. 2. Pyridoxine must receive additional basic and clinical investigations in this field.

References

Jan 1, 1975·International Archives of Allergy and Applied Immunology·J Wyczólkowska, C Maśliński
Oct 1, 1975·The Journal of Physiology·I B ChatterjeeN Subramanian
Jan 1, 1976·International Archives of Allergy and Applied Immunology·J Wyczólkowska, C Maśliński
Aug 1, 1977·Thorax·D W CockcroftF E Hargreave
Jan 1, 1979·The Journal of Allergy and Clinical Immunology·D W KordanskyP S Norman
Jan 1, 1976·International Archives of Allergy and Applied Immunology·J Wyczolkowska, A Prouvost-Danon
Jul 1, 1973·Biochemical Pharmacology·N SubramanianI B Chatterjee
Aug 1, 1974·Agents and Actions·E Bekier, C Maśliński
Jan 1, 1974·International Archives of Allergy and Applied Immunology·W A TaylorI M Roitt
Sep 1, 1965·The Journal of Pharmacy and Pharmacology·W Dawson, G B West
Aug 1, 1966·British Journal of Pharmacology and Chemotherapy·W DawsonG B West
Apr 1, 1973·The Journal of Allergy and Clinical Immunology·E ZuskinA Bouhuys
Jun 1, 1965·British Journal of Pharmacology and Chemotherapy·W DAWSON, G B WEST
Oct 1, 1967·British Journal of Pharmacology and Chemotherapy·W DawsonM A Stockham
Apr 2, 1938·British Medical Journal·H B Hunt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.