Ascorbic acid attenuates acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles

Journal of Occupational Health
Hiroko FukuiMasanori Horie

Abstract

It is known that inhalation of zinc oxide nanoparticles (ZnO NPs) induces acute pulmonary dysfunction, including oxidative stress, inflammation, and injury, but there are no reports on how to prevent these adverse effects. We have previously reported that the pulmonary symptoms caused by ZnO NPs were associated with oxidative stress; in the present study, we therefore investigated the use of ascorbic acid (AA), which is known as vitamin C, to prevent these toxic effects. A ZnO NP dispersion was introduced into rat lungs by intratracheal injection, and thereafter a 1% aqueous AA solution was given as drinking water. Bronchoalveolar lavage fluid was collected at 1 day and 1 week after injection, and lactate dehydrogenase (LDH) activity, heme oxygenase-1 (HO-1), and interleukin-6 (IL-6) levels were measured. In addition, expression of the chemokine cytokine-induced neutrophil chemoattractants (CINCs), HO-1, and metallothionein-1 (MT-1) genes in the lungs were determined. Acute oxidative stress induced by ZnO NPs was suppressed by supplying AA. Increases in LDH activity and IL-6 concentration were also suppressed by AA, as was the expression of the CINC-1, CINC-3, and HO-1 genes. Oral intake of AA prevents acute pulmonary oxidative...Continue Reading

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Citations

Nov 26, 2015·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Yasuo MorimotoTakeshi Sasaki
Sep 9, 2016·Frontiers in Behavioral Neuroscience·Caroline C de OliveiraRaquel C R Martinez
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Dec 1, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Pavel RossnerJan Topinka
Jul 17, 2019·Current Medicinal Chemistry·Ken-Ichiro Tanaka, Masahiro Kawahara
Mar 1, 2021·Journal of Applied Toxicology : JAT·Anupam SarmaSatyendra Deka

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