Ascorbic acid deficiency stimulates hepatic expression of inflammatory chemokine, cytokine-induced neutrophil chemoattractant-1, in scurvy-prone ODS rats

Journal of Nutritional Science and Vitaminology
F HorioTakanori Tsuda

Abstract

ODS rat has a hereditary defect in ascorbic acid biosynthesis and is a useful animal model for elucidating the physiological role of ascorbic acid. We previously demonstrated by using ODS rats that ascorbic acid deficiency changes the hepatic gene expression of acute phase proteins, as seen in acute inflammation. In this study, we investigated the effects of ascorbic acid deficiency on the production of inflammatory chemokine, cytokine-induced neutrophil chemoattractant-1 (CINC-1), in ODS rats. Male ODS rats (6 wk of age) were fed a basal diet containing ascorbic acid (300 mg/kg diet) or a diet without ascorbic acid for 14 d. Obvious symptoms of scurvy were not observed in the ascorbic acid-deficient rats. Ascorbic acid deficiency significantly elevated the serum concentration of CINC-1 on d 14. The liver and spleen CINC-1 concentrations in the ascorbic acid-deficient rats were significantly elevated to 600% and 180% of the respective values in the control rats. However, the lung concentration of CINC-1 was not affected by ascorbic acid deficiency. Ascorbic acid deficiency significantly elevated the hepatic mRNA level of CINC-1 (to 480% of the value in the control rats), but not the lung mRNA level. These results demonstrate th...Continue Reading

References

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Citations

Mar 26, 2009·Journal of Paediatrics and Child Health·Agata VitaleFrancesco Zulian
Dec 24, 2014·Nutrients·David Højland IpsenJens Lykkesfeldt
Jan 20, 2016·Zeitschrift für Rheumatologie·K HofheinzB Manger
Jun 24, 2011·Kidney International·Oluwatoyin F Bamgbola
Jul 24, 2012·Biochimica Et Biophysica Acta·Motoko TakahashiYoshio Kuroki
Apr 10, 2015·Current Rheumatology Reports·Claudia FerrariCarlo Salvarani
Dec 28, 2010·Seminars in Arthritis and Rheumatism·Marty T Mertens, Elie Gertner
Jan 15, 2019·Redox Biology·Maret G TraberRichard S Bruno

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