Ascorbic acid improves brachial artery vasodilation during progressive handgrip exercise in the elderly through a nitric oxide-mediated mechanism

American Journal of Physiology. Heart and Circulatory Physiology
Joel D TrinityRussell S Richardson

Abstract

The proposed mechanistic link between the age-related attenuation in vascular function and free radicals is an attractive hypothesis; however, direct evidence of free radical attenuation and a concomitant improvement in vascular function in the elderly is lacking. Therefore, this study sought to test the hypothesis that ascorbic acid (AA), administered intra-arterially during progressive handgrip exercise, improves brachial artery (BA) vasodilation in a nitric oxide (NO)-dependent manner, by mitigating free radical production. BA vasodilation (Doppler ultrasound) and free radical outflow [electron paramagnetic resonance (EPR) spectroscopy] were measured in seven healthy older adults (69 ± 2 yr) during handgrip exercise at 3, 6, 9, and 12 kg (∼13-52% of maximal voluntary contraction) during the control condition and nitric oxide synthase (NOS) inhibition via N(G)-monomethyl-L-arginine (L-NMMA), AA, and coinfusion of l-NMMA + AA. Baseline BA diameter was not altered by any of the treatments, while L-NMMA and L-NMMA + AA diminished baseline BA blood flow and shear rate. AA improved BA dilation compared with control at 9 kg (control: 6.5 ± 2.2%, AA: 10.9 ± 2.5%, P = 0.01) and 12 kg (control: 9.5 ± 2.7%, AA: 15.9 ± 3.7%, P < 0.01). ...Continue Reading

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Citations

Jul 2, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Steven A RomeroCraig G Crandall
Nov 10, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Seul-Ki ParkJ David Symons
Jan 29, 2019·The Journal of Physiology·Oh Sung KwonRussell S Richardson
Aug 18, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Thales C BarbosaPaul J Fadel
Feb 20, 2018·Diabetology & Metabolic Syndrome·Rebecca L ScalzoJudith G Regensteiner
Oct 4, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Daniel R MachinAnthony J Donato
Aug 24, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Joshua C TremblayKyra E Pyke
Aug 18, 2020·Medicine and Science in Sports and Exercise·Trevor J KingJamie F Burr
Feb 23, 2021·Journal of the American Heart Association·Mary Rezk-HannaNeal L Benowitz

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