Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly

Cancer Cell
Niraj ShenoyM Levine

Abstract

Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and discovery of unexpected mechanisms of ascorbate action have spawned many investigations. Two mechanisms of anti-cancer activity with ascorbate have gained prominence: hydrogen peroxide-induced oxidative stress and DNA demethylation mediated by ten-eleven translocation enzyme activation. Here, we highlight salient aspects of the evolution of ascorbate in cancer treatment, provide insights into the pharmacokinetics of ascorbate, describe mechanisms of its anti-cancer activity in relation to the pharmacokinetics, outline promising preclinical and clinical evidence, and recommend future directions.

Citations

Feb 1, 2019·The Journal of Clinical Investigation·Niraj ShenoyAmit Verma
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Dec 11, 2019·JCI Insight·Pierre-Christian VioletMark Levine
Jan 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rebecca A LuchtelNiraj Shenoy
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