Ascorbic acid infusion blunts CD40L upregulation in patients undergoing coronary stent

Cardiovascular Therapeutics
Pasquale PignatelliFrancesco Violi

Abstract

To reduce the increase of oxidative stress and the upregulation of CD40L during stenting procedure using ascorbic acid infusion. CD40L upregulation occurring after coronary percutaneous coronary intervention predicts vascular events but the underlying mechanism is still unclear. Fifty-six patients undergoing elective coronary stenting were randomly allocated to intravenous infusion of the antioxidant ascorbic acid or placebo. Platelet CD40L and plasma levels of soluble CD40L and of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, were measured before and after coronary stenting. In vitro study was also done to measure reactive oxidant species and CD40L expression in platelets exposed to anoxia-reoxygenation. Placebo-treated patients showed a significant increase of platelet CD40L, soluble CD40L and 8-hydroxy-2'-deoxyguanosine compared to baseline values. Patients given ascorbic acid showed no change of soluble CD40L and platelet CD40L but a significant decrease of 8-hydroxy-2'-deoxyguanosine. After 60 and 120 min, soluble CD40L, platelet CD40L and 8-hydroxy-2'-deoxyguanosine were significantly lower in the ascorbic acid-treated group compared to the placebo-treated one. A significant correlation between platelet CD40L...Continue Reading

Associated Clinical Trials

References

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Citations

Apr 8, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Francesco VioliLorenzo Loffredo
Jan 10, 2014·Thrombosis and Haemostasis·Francesco Violi, Pasquale Pignatelli
Sep 28, 2012·Thrombosis and Haemostasis·Patrizia FerroniGiovanni Davì
Jul 15, 2015·Antioxidants & Redox Signaling·Harald H H W SchmidtAntonio Cuadrado
Apr 8, 2015·Prostaglandins & Other Lipid Mediators·Daniele PastoriFrancesco Violi
Jan 31, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Mette M Berger, Heleen M Oudemans-van Straaten
Jul 21, 2011·Acta Anaesthesiologica Scandinavica·P PignatelliG Delogu
Apr 3, 2019·Nutrients·Harri Hemilä, Elizabeth Chalker
May 2, 2020·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Demin LiuWei Cui

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