Ascorbic acid protects against cadmium-induced endoplasmic reticulum stress and germ cell apoptosis in testes

Reproductive Toxicology
Yan-Li JiDe-Xiang Xu

Abstract

Cadmium (Cd) is a testicular toxicant which induces endoplasmic reticulum (ER) stress and germ cell apoptosis in testes. This study investigated the effects of ascorbic acid on Cd-evoked ER stress and germ cell apoptosis in testes. Male mice were intraperitoneally injected with CdCl(2) (2.0 mg/kg). As expected, a single dose of Cd induced testicular germ cell apoptosis. Interestingly, Cd-triggered testicular germ cell apoptosis was almost completely inhibited in mice treated with ascorbic acid. Interestingly, ascorbic acid significantly attenuated Cd-induced upregulation of GRP78 in testes. In addition, ascorbic acid significantly attenuated Cd-triggered testicular IRE1α and eIF2α phosphorylation and XBP-1 activation, indicating that this antioxidant counteracts Cd-induced unfolded protein response (UPR) in testes. Finally, ascorbic acid significantly attenuated Cd-evoked upregulation of CHOP and JNK phosphorylation, two components in ER stress-mediated apoptotic pathway. In conclusion, ascorbic acid protects mice from Cd-triggered germ cell apoptosis via inhibiting ER stress and UPR in testes.

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Citations

Aug 21, 2013·In Vitro Cellular & Developmental Biology. Animal·Chao WeiYunhai Zhang
Aug 29, 2013·Archives of Toxicology·Frank Thévenod, Wing-Kee Lee
Jan 26, 2016·International Journal of Molecular Sciences·Adolf Michael Sandbichler, Martina Höckner
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Apr 30, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Si ChenPeng Li

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