Ascorbic acid repletion: A possible therapy for diabetic macular edema?

Free Radical Biology & Medicine
James M May

Abstract

Macular edema poses a significant risk for visual loss in persons with diabetic retinopathy. It occurs when plasma constituents and fluid leak out of damaged retinal microvasculature in the area of the macula, causing loss of central vision. Apoptotic loss of pericytes surrounding capillaries is perhaps the earliest feature of diabetic vascular damage in the macula, which is also associated with dysfunction of the endothelium and loss of the otherwise very tight endothelial permeability barrier. Increased oxidative stress is a key feature of damage to both cell types, mediated by excess superoxide from glucose-induced increases in mitochondrial metabolism, as well as by activation of the receptor for advanced glycation end products (RAGE). The latter in turn activates multiple pathways, some of which lead to increased oxidative stress, such as those involving NF-ĸB, NADPH oxidase, and endothelial nitric oxide synthase. Such cellular oxidative stress is associated with low cellular and plasma ascorbic acid levels in many subjects with diabetes in poor glycemic control. Whether repletion of low ascorbate in retinal endothelium and pericytes might help to prevent diabetic macular edema is unknown. However, cell culture studies sho...Continue Reading

References

Jun 1, 1976·The Biochemical Journal·B Halliwell, C H Foyer
Oct 1, 1979·Analytical Biochemistry·I B Chatterjee, A Banerjee
Aug 14, 1991·JAMA : the Journal of the American Medical Association
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Apr 3, 1986·The New England Journal of Medicine·M Levine
Mar 1, 1966·The British Journal of Ophthalmology·F de Oliveira
Nov 1, 1995·Diabetes·S M Baumgartner-ParzerW Waldhäusl
May 1, 1995·Journal of Cellular Physiology·N UtoguchiT Mayumi
Aug 1, 1994·Journal of Bioenergetics and Biomembranes·W W Wells, D P Xu
Jan 1, 1995·Free Radical Biology & Medicine·D BartlettW H Koppenol
Jun 1, 1997·European Journal of Clinical Investigation·S R MaxwellA H Barnett
Mar 21, 1998·Journal of the American College of Cardiology·F K TimimiM A Creager
Aug 30, 2000·Journal of the American College of Nutrition·S J Padayatty, M Levine
Feb 7, 2001·Circulation Research·U HinkT Munzel
Feb 2, 2002·Science·Richard K Bruick, Steven L McKnight
Feb 21, 2002·Biochimica Et Biophysica Acta·Oreste Arrigoni, Mario C De Tullio
Apr 12, 2002·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Yoshiji OhtaMasayuki Horiguchi
Sep 28, 2002·Diabetes·Hans-Peter HammesUrban Deutsch
Jan 5, 2005·Archives of Biochemistry and Biophysics·James M May, Zhi-chao Qu
May 14, 2005·Diabetes/metabolism Research and Reviews·Shigeru YatohNobuhiro Yamada
Mar 1, 2006·The Journal of Biological Chemistry·Antonia G MillerRam H Nagaraj
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Jason D HuberKimberly A Houser
Jan 5, 2007·Journal of Cellular Biochemistry·Feng M HoChiau S Liau
Feb 27, 2007·Free Radical Biology & Medicine·Margret C M VissersMargaret J Currie
Sep 26, 2007·Free Radical Biology & Medicine·Timothy P CashM Celeste Simon
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Qi ChenMark Levine

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