Ascorbic acid supplementation causes faster restoration of reduced glutathione content in the regression of alcohol-induced hepatotoxicity in male guinea pigs.

Redox Report : Communications in Free Radical Research
P A AbhilashM Indira

Abstract

Alcoholic liver disease is caused mainly by free radicals. Ascorbic acid (AA) and glutathione (GSH) are the major water-soluble antioxidants in the liver. The impact of AA supplementation on GSH, AA and activities of GSH-dependent enzymes in alcoholic guinea pigs was studied and was compared with alcohol abstention. Guinea pigs were administered ethanol at a dose of 4 g/kg body weight (b.wt)/day for 90 days. After 90 days, alcohol administration was stopped and one-half of the ethanol-treated animals were supplemented with AA (25 mg/100 g b.wt) for 30 days and the other half was maintained as the abstention group. There was a significant increase in the activities of alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase in the serum of the ethanol group. In addition, a significant decrease in the GSH content, activities of GSH peroxidase, GSH reductase, and increased activity of GSH-S-transferase were observed in the liver of the ethanol group. Histopathological analysis and triglycerides content in the liver of the ethanol group showed induction of steatosis. But AA supplementation and abstention altered the changes caused by ethanol. However, maximum protective effect was observed in the AA-s...Continue Reading

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Citations

Apr 23, 2013·Redox Report : Communications in Free Radical Research·Johanna M GostnerRobert Sucher
Feb 12, 2013·Redox Report : Communications in Free Radical Research·P PrathibhaM Indira
Oct 16, 2012·Circulation Research·Dieter A Kubli, Åsa B Gustafsson
Jan 23, 2013·The British Journal of Nutrition·R HarikrishnanM Indira
May 12, 2019·Critical Care : the Official Journal of the Critical Care Forum·Paul E Marik, Amanda Liggett
Oct 10, 2020·Heart Failure Reviews·Akshi MalikPawan K Singal
Feb 23, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Seong-Hoon ParkSae-Ron Shin

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