Asenapine for the Treatment of Psychotic Disorders

Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie
Catherine OrrKamini Vasudev


A systematic review was conducted to examine the efficacy, tolerability, and acceptability of asenapine compared with other antipsychotics in the treatment of psychotic disorders. Four databases, 8 trial registries, and conference presentations were searched for randomized clinical trials of asenapine versus any comparator for the treatment of any psychotic illness. Primary outcome measures were changes in the Positive and Negative Syndrome Scale (PANSS) total score and the incidence of withdrawal due to adverse effects. Eight randomized clinical trials, encompassing 3765 patients, that compared asenapine with placebo ( n = 5) and olanzapine ( n = 3) were included. No differences were found between asenapine and olanzapine in terms of changes to PANSS total or PANSS negative subscale scores. Patients taking asenapine were more likely to experience worsening schizophrenia and/or psychosis than were those taking olanzapine. No differences were found between asenapine and olanzapine in rates of discontinuation due to adverse drug reactions or lack of efficacy, but those taking asenapine had higher rates of withdrawal for any reason than those taking olanzapine. Asenapine caused less clinically significant weight gain or increases ...Continue Reading


Oct 27, 2007·The Journal of Clinical Psychiatry·Steven G PotkinJohn Panagides
Dec 27, 2011·Journal of Clinical Psychopharmacology·Robert W BuchananPilar Cazorla

Related Concepts

Metabolic Process, Cellular
Antipsychotic Effect
Meta-Analysis (Publications)
Other antipsychotics in ATC
Clinical Trials, Randomized
Extrapyramidal Sign
Adverse Effects

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