Aseptic meningitis in an adult population. Etiology and utility of molecular techniques in the clinical management of patients

Enfermedades infecciosas y microbiología clínica
Laura Florén-ZabalaMaría José Pena-López

Abstract

This study describes the epidemiological, clinical and microbiological features of acute aseptic meningitis (AAM) in an adult population, and evaluates the impact of microbiological results on the clinical management of patients. Cases of AAM were prospectively collected between 2007 and 2010 among immunocompetent patients over 14 years-old. Enteroviruses and herpes viruses were determined using nucleic acids detection in CSF. Demographic and clinical data were retrospectively collected from medical records. A total of 94 patients were included, of whom 84 were diagnosed with viral meningitis (VM). The annual incidence of VM ranged from 2.4 to 15.3 cases per 100,000 inhabitants. An aetiological diagnosis was obtained in 76.2% of the patients with VM, 55 enterovirus, 4 HSV-2, 3 VZV, one HSV-1, and one EBV. Forty five per cent of patients were admitted to hospital and 65.8% of them received antibiotic treatment. A positive result prompted immediate discharge of 80% of inpatients and discontinuation of antibiotic therapy in 94.1% of them. The median duration of admission to hospital in these patients was 2.8±2.9 days. Patients without available results during admission completed the antibiotic treatment, and the median hospital st...Continue Reading

References

Apr 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S K RiceS M Opal
Jan 1, 1993·Scandinavian Journal of Infectious Diseases·M GlimåkerM Forsgren
Nov 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·H A RotbartF G Hayden
Oct 29, 2000·Seminars in Neurology·H A Rotbart
Jun 19, 2002·Scandinavian Journal of Infectious Diseases·Pierre TattevinChristian Michelet
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·D A NowakH-H Fuchs
May 12, 2004·Heart & Lung : the Journal of Critical Care·Lawrence E EisensteinBurke A Cunha
Jan 19, 2006·Clinical Microbiology Reviews·M J EspyT F Smith
May 14, 2008·Archives of Neurology·Joseph R Berger, Sidney Houff
Jul 11, 2008·Scandinavian Journal of Infectious Diseases·Elisabeth Franzen-RohlMartin Glimåker
Jul 22, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F FrantzidouA Papa
Aug 6, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ugo K IhekwabaMichael W McKendrick
Dec 17, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·G TralleroM Cabrerizo
Dec 18, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L NinoveX de Lamballerie
Mar 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I SteinerP G E Kennedy
May 17, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M KleinesM Häusler

❮ Previous
Next ❯

Citations

Dec 7, 2016·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·Natalia Alonso PérezJosé Tomás Ramos Amador
Apr 30, 2017·Revista de salud pública·Vaneza TiqueLuiz T Moraes-Figueiredo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of STD & AIDS
P FarazmandG R Kinghorn
The New England Journal of Medicine
M N Swartz
Enfermedades infecciosas y microbiología clínica
M Lirios JuliáAntonio Guerrero
The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Vitor Laerte Laerte Pinto JuniorMarcio Neves Bóia
Enfermedades infecciosas y microbiología clínica
Iría Jesús-De La CalleEfraín Cruz-Rosales
© 2022 Meta ULC. All rights reserved