PMID: 9549405Jan 1, 1997Paper

Asialoglycoprotein (ASGP) receptors induced by apoptosis. Their immunohistochemical localization in neonatal rat hepatocytes

Rivista di biologia
L Dini

Abstract

Immunohistochemical detection of asialoglycoprotein (ASGP) receptors has been performed on neonatal rat hepatocytes in primary cultures, incubated with TGF beta, TNF alpha and retinoic acid. These substances account for the increase in the rate of apoptosis of the cell cultures and for the increase of the expression of ASGP receptors. Both modifications are higher at 24 hours of incubation.

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis