Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction

Experimental and Therapeutic Medicine
Lianying HuoYufeng Li

Abstract

Left ventricular remodeling results in cardiac dysfunction and accounts for the majority of the morbidity and mortality following myocardial infarction (MI). The aim of the present study was to investigate the effect of asiatic acid (AA) on cardiac function and left ventricular remodeling in a rat model of MI and explore the underlying mechanisms. Rats were subjected to coronary artery ligation to model MI and orally treated with AA. After 4 weeks, cardiac function was assessed by echocardiography. Cardiomyocyte cross-sectional area was recorded, and the expression levels of a number of inflammatory cytokines were detected using ELISA. The degree of interstitial fibrosis was determined by evaluating the mRNA expression levels of collagen II and III. Western blot analysis was performed to detect the expression levels of total and phosphorylated p38 MAPK and ERK1/2, to investigate whether they are involved in the mechanism underlying the effect of AA on the heart. Rats subjected to MI displayed significantly impaired cardiac function compared with those subjected to a sham procedure, while this change was reversed by treatment with AA. Furthermore, AA markedly inhibited cardiac hypertrophy, reduced the mRNA expression levels of i...Continue Reading

References

Sep 18, 1998·European Heart Journal·H D White, E Braunwald
Dec 16, 1998·Clinical Cardiology·K KurrelmeyerD L Mann
Apr 6, 2005·Journal of Molecular and Cellular Cardiology·Jie RenAnthony J Muslin
Jan 31, 2006·Lancet·Lionel H OpieMarc A Pfeffer
Nov 18, 2006·Cardiovascular Research·Marcin Bujak, Nikolaos G Frangogiannis
Apr 22, 2009·Journal of Neuroscience Research·Rajanikant G KrishnamurthyArshad Majid
May 18, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Shyh-Shyun HuangGuan-Jhong Huang
Dec 20, 2011·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Dec 31, 2011·Lipids in Health and Disease·Linn E FosshaugErik Øie
Oct 1, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Vinayagam RamachandranPoomalai Senthilraja
Aug 1, 2015·Journal of Molecular and Cellular Cardiology·Di ZhuLing Tao

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Citations

Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiang HuangYisong Qian
Nov 6, 2018·Regenerative Engineering and Translational Medicine·Timothy Chen, Gordana Vunjak-Novakovic
Oct 27, 2020·Journal of Cardiovascular Pharmacology·Vanessa Duarte OrtizAlex Sander da Rosa Araujo
Dec 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Faeze KeihanianSaeid Madaeni

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Methods Mentioned

BETA
light microscopy
enzyme-linked immunosorbent assay
Protein Assay
PCR
ELISA

Software Mentioned

ImagePro Plus
SPSS
VisionWorks LS
Primer Express
TruScan

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