ASIC3-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia

Brain Research
T FukudaT Sugimoto

Abstract

ASIC3-immunoreactivity (ir) was examined in the rat vagal and glossopharyngeal sensory ganglia. In the jugular, petrosal and nodose ganglia, 24.8%, 30.8% and 20.6% of sensory neurons, respectively, were immunoreactive for ASIC3. These neurons were observed throughout the ganglia. A double immunofluorescence method demonstrated that many ASIC3-immunoreactive (ir) neurons co-expressed calcitonin gene-related peptide (CGRP)- or vanilloid receptor subtype 1 (VRL-1)-ir in the jugular (CGRP, 77.8%; VRL-1, 28.0%) and petrosal ganglia (CGRP, 61.7%; VRL-1, 21.5%). In the nodose ganglion, however, such neurons were relatively rare (CGRP, 6.3%; VRL-1, 0.4%). ASIC3-ir neurons were mostly devoid of tyrosine hydroxylase in these ganglia. However, some ASIC3-ir neurons co-expressed calbindin D-28k in the petrosal (5.5%) and nodose ganglia (3.8%). These findings may suggest that ASIC3-containing neurons have a wide variety of sensory modalities in the vagal and glossopharyngeal sensory ganglia.

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Citations

Jan 12, 2012·Pharmacology & Therapeutics·Wei-Li WuChih-Cheng Chen
Sep 3, 2010·Pharmacology & Therapeutics·Emmanuel DevalEric Lingueglia
Apr 20, 2007·Journal of Cellular Physiology·Ulyana LaloAlexei Verkhratsky
Mar 1, 2015·Neuropharmacology·Emmanuel Deval, Eric Lingueglia
Jan 15, 2015·Neuropharmacology·Peter Holzer
Jul 5, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D Alvarez-BerdugoP Clavé
May 1, 2010·Expert Review of Clinical Pharmacology·Jacques NoëlEric Lingueglia
Jun 6, 2019·Physiology·Tymoteusz ZeraJulian F R Paton
Sep 6, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·X LiuS J Fidone
Oct 1, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Mohammad Zakir HossainJunichi Kitagawa
Sep 2, 2020·International Journal of Molecular Sciences·Mohammad Zakir HossainJunichi Kitagawa
Dec 2, 2020·Channels·Jasdip Singh DulaiTaufiq Rahman

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