Asparaginase Erwinia chrysanthemi as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia who have developed hypersensitivity to E. coli-derived asparaginase

Expert Review of Hematology
Lisa FigueiredoRichard A Drachtman

Abstract

Asparaginase has been a mainstay of therapy in the treatment of acute lymphoblastic leukemia since the 1970s. There are two major preparations available and FDA approved in the United States today, one derived from Escherichia coli and the other from Erwinia chrysanthemi. Erwinia asparaginase is antigenically distinct from and has a considerably shorter biological half-life than E coli asparaginase. Erwinia asparaginase has been used in cases of hypersensitivity to E. coli-derived asparaginases, which has been reported in up to 30% of patients. While PEG asparaginase is increasingly used in front-line therapy for ALL, hypersensitivity still occurs with this preparation, and a change to a non-cross-reactive preparation may be necessary.

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Citations

Jun 3, 2016·Applied Microbiology and Biotechnology·Boyang ZhangDianwen Ju
Jul 3, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Peng ZhangShaoyi Jiang
Mar 30, 2017·Applied Microbiology and Biotechnology·Yunxiang JiDianwen Ju
Apr 17, 2017·Experimental Hematology·Stéphane LepretreNicolas Boissel
Mar 13, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lindsey Phillipson-WeinerTracy G Anthony
Sep 26, 2017·Clinical Journal of Oncology Nursing·Van Thu Huynh, Sharon Bergeron

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