PMID: 6109000Oct 1, 1980Paper

Asparagine as precursor for transmitter aspartate in corticostriatal fibres

Journal of Neurochemistry
J C ReubiM Cuenod

Abstract

The role of asparagine as precursor for the neurotransmitter aspartate was investigated in rat striatum in vitro. 14C-asparagine incubated with striatal slices is converted to a great extent to 14C-aspartate which is released in a calcium-dependent manner by high KCl. Furthermore, a frontoparietal cortex ablation of two weeks produces a decrease of more than 70% in the striatal release of newly synthetized 14C-aspartate, whereas the striatal GABA release is unaffected. This suggests that asparagine is a possible precursor in vitro for transmitter aspartate in the striatum. This reaction is dependent on intact corticostriatal fibres.

References

Oct 26, 1979·Brain Research·J C Reubi, M Cuenod
Aug 11, 1978·Brain Research·T M Jessell
Jun 10, 1977·Brain Research·P L McGeerK Singh
Jun 25, 1976·Brain Research·H F Bradford, H K Ward
Nov 1, 1969·Journal of Neurochemistry·H F Bradford, A J Thomas
Feb 1, 1980·Biochemical Pharmacology·G A Nimmo, K F Tipton
Nov 1, 1978·Neuroscience Letters·J C ReubiM Cuénod

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Citations

Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluF Aricioğlu
Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·H KoyuncuŏgluY Esin
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·H KoyuncuoğluU Sayin
Jan 1, 1983·Progress in Neurobiology·E Kvamme
Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Jun 1, 1986·Journal of Neurochemistry·J D Rothstein, B Tabakoff
Jul 29, 2017·Journal of Hematology & Oncology·Marcus Kwong Lam Fung, Godfrey Chi-Fung Chan

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