Asparagus adscendens (Shweta musali) stimulates insulin secretion, insulin action and inhibits starch digestion

The British Journal of Nutrition
Jacqueline N MathewsYasser H A Abdel-Wahab

Abstract

Diabetes mellitus is a complex metabolic disease characterised by glucose overproduction and under-utilisation. As the incidence of diabetes expands rapidly across the globe there is an urgent need to expand the range of effective treatments. Higher plants such as Asparagus adscendens provide therapeutic opportunities and a rich source of potential antidiabetic agents. In the present study an aqueous extract of Asparagus adscendens was shown to induce a significant non-toxic 19-248 % increase in glucose-dependent insulinotropic actions (P < 0.001) in the clonal pancreatic beta cell line, BRIN-BD11. In addition, the extract produced an 81 % (P < 0.0001) increase in glucose uptake in 3T3-L1 adipocytes. Asparagus adscendens also produced a 21 % (P < 0.001) decrease in starch digestion in vitro. The present study has revealed the presence of insulinotropic, insulin-enhancing activity and inhibitory effects on starch digestion in Asparagus adscendens. The former actions are dependent on the active principle(s) in the plant being absorbed intact. Future work assessing its use as a dietary adjunct or as a source of active components may provide new opportunities for the treatment of diabetes.

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Citations

Jan 1, 2008·Biological Chemistry·Yasser H A Abdel-WahabJ Michael Conlon
Jun 16, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Zainah AdamMuhajir Hamid
Jan 6, 2018·Reviews in the Neurosciences·Sita Sharan PatelSurendra Kumar Jain
Apr 12, 2012·Natural Product Reports·Hsin-Yi HungKuo-Hsiung Lee
Aug 2, 2012·International Journal of Food Sciences and Nutrition·Senadheera Pathirannehelage Anuruddhika Subhashinie Senadheera, Sagarika Ekanayake
Mar 2, 2018·Therapeutic Advances in Endocrinology and Metabolism·Sudhanshu Kumar BhartiAwanish Kumar

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