PMID: 6978332Jan 1, 1982Paper

Asparenomycins A, B and C, new carbapenem antibiotics. V. Inhibition of beta-lactamases

The Journal of Antibiotics
K MurakamiT Yoshida

Abstract

Asparenomycins (ASMs) A, B and C inhibited a wide range of beta-lactamases including both cephalosporinases and penicillinases usually at concentrations less than 3 microM. On studying the mechanism of inhibition of beta-lactamases produced by Gram-negative bacteria by ASM A it was concluded that ASM A inhibited the beta-lactamases by acylating the enzymes. This conclusion was reached from the following observations. i) The inhibition was progressive with time. ii) The inhibitor formed stable complexes with the enzyme. iii) Before completing inhibition of one molecule of the enzyme, 1.8 molecules of the inhibitor were hydrolyzed.

Citations

Jan 1, 1988·Journal of Enzyme Inhibition·R B Silverman
Dec 14, 2006·Organic & Biomolecular Chemistry·Carol C Ruddle, Timothy P Smyth
Oct 1, 1983·Medicinal Research Reviews·S J Cartwright, S G Waley
Aug 24, 2011·Antimicrobial Agents and Chemotherapy·Krisztina M Papp-WallaceRobert A Bonomo
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Malcolm G. P. Page
May 1, 1985·Antimicrobial Agents and Chemotherapy·K Murakami, T Yoshida

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