"Aspartame: A review of genotoxicity data"

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
David Kirkland, David Gatehouse

Abstract

Aspartame is a methyl ester of a dipeptide of aspartic acid and phenylalanine. It is 200× sweeter than sucrose and is approved for use in food products in more than 90 countries around the world. Aspartame has been evaluated for genotoxic effects in microbial, cell culture and animal models, and has been subjected to a number of carcinogenicity studies. The in vitro and in vivo genotoxicity data available on aspartame are considered sufficient for a thorough evaluation. There is no evidence of induction of gene mutations in a series of bacterial mutation tests. There is some evidence of induction of chromosomal damage in vitro, but this may be an indirect consequence of cytotoxicity. The weight of evidence from in vivo bone marrow micronucleus, chromosomal aberration and Comet assays is that aspartame is not genotoxic in somatic cells in vivo. The results of germ cell assays are difficult to evaluate considering limited data available and deviations from standard protocols. The available data therefore support the conclusions of the European Food Safety Authority (EFSA) that aspartame is non-genotoxic.

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Citations

Apr 24, 2020·Drug and Chemical Toxicology·Dhamraa W Al-DulaimiLoiy E Ahmed Hassan
Mar 8, 2018·BioMed Research International·Samuel Durán AgüeroJorge de Assis Costa
Sep 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dorin HarpazEvgeni Eltzov

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