Aspartame ingestion increases urinary calcium, but not oxalate excretion, in healthy subjects

The Journal of Clinical Endocrinology and Metabolism
U N NguyenJ Regnard

Abstract

Aspartame is the artificial sweetener most extensively used as a substitute for glucose or sucrose in the food industry, particularly in soft drinks. As glucose ingestion increases calciuria and oxaluria, the two main determinants of urinary calcium-oxalate saturation, we considered it worthwhile to determine whether aspartame ingestion also affects calcium-oxalate metabolism. Our study compares the effects of the ingestion of similarly sweet doses of aspartame (250 mg) and glucose (75 g) on calcium and oxalate metabolisms of seven healthy subjects. Urinary calcium excretion increased after the intake of both aspartame (+86%; P < 0.01) and glucose (+124%; P < 0.01). This may be due to the rise in calcemia observed after both aspartame (+2.2%; P < 0.05) and glucose ingestion (+1.8%; P < 0.05). The increased calcemia may be linked to the decrease in phosphatemia that occurred after both aspartame (P < 0.01) and glucose (P < 0.01) load. Aspartame did not alter glycemia or insulinemia, whereas glucose intake caused striking increases in both glycemia (+59%; P < 0.001) and insulinemia (+869%; P < 0.01). Although insulin was considered the main calciuria-induced factor after glucose load, it is unlikely that this mechanism played a r...Continue Reading

Citations

Oct 19, 2006·Toxicology and Applied Pharmacology·Jaydip DasguptaDouglas G Tincello
May 30, 2014·International Journal of Toxicology·M AbhilashR Harikumaran Nair
May 16, 2018·European Journal of Clinical Nutrition·Alexander D NicholRuopeng An
Feb 5, 2005·Journal of Applied Physiology·S R ZwartS M Smith
Nov 20, 2019·Current Atherosclerosis Reports·Yoona KimPeter M Clifton
Jul 25, 2020·International Journal of Environmental Health Research·Rasha Y M IbrahimAbdullah A Saber
Aug 16, 2002·Regulatory Toxicology and Pharmacology : RTP·Harriett H ButchkoFriedrich K Trefz

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